Simultaneous imaging of protonated and deprotonated carbonylcyanide p-trifluoromethoxyphenylhydrazone in live cells by Raman microscopy

Hiroyuki Yamakoshi, Almar F. Palonpon, Kosuke Dodo, Jun Ando, Satoshi S. Kawat, Katsumasa Fujita, Mikiko Sodeoka

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)

Abstract

We report the simultaneous imaging of protonated and deprotonated forms of carbonylcyanide p-trifluoromethoxy-phenylhydrazone (FCCP) molecules in live cells by Raman microscopy. Nitriles, structure-sensitive Raman tags, are used to detect the two distinct molecular structures, demonstrating the potential of Raman microscopy for structure-based imaging of bioactive small molecules.

Original languageEnglish
Pages (from-to)1341-1343
Number of pages3
JournalChemical Communications
Volume50
Issue number11
DOIs
Publication statusPublished - 2014 Jan 9
Externally publishedYes

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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