Simultaneous imaging of protonated and deprotonated carbonylcyanide p-trifluoromethoxyphenylhydrazone in live cells by Raman microscopy

Hiroyuki Yamakoshi; Almar F. Palonpon; Kosuke Dodo; Jun Ando; Satoshi S. Kawat; Katsumasa Fujita; Mikiko Sodeoka

doi:10.1039/c3cc48587k

Simultaneous imaging of protonated and deprotonated carbonylcyanide p-trifluoromethoxyphenylhydrazone in live cells by Raman microscopy

Hiroyuki Yamakoshi, Almar F. Palonpon, Kosuke Dodo, Jun Ando, Satoshi S. Kawat, Katsumasa Fujita, Mikiko Sodeoka

Research output: Contribution to journal › Article › peer-review

34 Citations (Scopus)

Abstract

We report the simultaneous imaging of protonated and deprotonated forms of carbonylcyanide p-trifluoromethoxy-phenylhydrazone (FCCP) molecules in live cells by Raman microscopy. Nitriles, structure-sensitive Raman tags, are used to detect the two distinct molecular structures, demonstrating the potential of Raman microscopy for structure-based imaging of bioactive small molecules.

Original language	English
Pages (from-to)	1341-1343
Number of pages	3
Journal	Chemical Communications
Volume	50
Issue number	11
DOIs	https://doi.org/10.1039/c3cc48587k
Publication status	Published - 2014 Jan 9
Externally published	Yes

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

Access to Document

10.1039/c3cc48587k

Cite this

@article{592062502bc542f7a75b81645d39fccb,

title = "Simultaneous imaging of protonated and deprotonated carbonylcyanide p-trifluoromethoxyphenylhydrazone in live cells by Raman microscopy",

abstract = "We report the simultaneous imaging of protonated and deprotonated forms of carbonylcyanide p-trifluoromethoxy-phenylhydrazone (FCCP) molecules in live cells by Raman microscopy. Nitriles, structure-sensitive Raman tags, are used to detect the two distinct molecular structures, demonstrating the potential of Raman microscopy for structure-based imaging of bioactive small molecules.",

author = "Hiroyuki Yamakoshi and Palonpon, {Almar F.} and Kosuke Dodo and Jun Ando and Kawat, {Satoshi S.} and Katsumasa Fujita and Mikiko Sodeoka",

year = "2014",

month = jan,

day = "9",

doi = "10.1039/c3cc48587k",

language = "English",

volume = "50",

pages = "1341--1343",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

number = "11",

}

TY - JOUR

T1 - Simultaneous imaging of protonated and deprotonated carbonylcyanide p-trifluoromethoxyphenylhydrazone in live cells by Raman microscopy

AU - Yamakoshi, Hiroyuki

AU - Palonpon, Almar F.

AU - Dodo, Kosuke

AU - Ando, Jun

AU - Kawat, Satoshi S.

AU - Fujita, Katsumasa

AU - Sodeoka, Mikiko

PY - 2014/1/9

Y1 - 2014/1/9

N2 - We report the simultaneous imaging of protonated and deprotonated forms of carbonylcyanide p-trifluoromethoxy-phenylhydrazone (FCCP) molecules in live cells by Raman microscopy. Nitriles, structure-sensitive Raman tags, are used to detect the two distinct molecular structures, demonstrating the potential of Raman microscopy for structure-based imaging of bioactive small molecules.

AB - We report the simultaneous imaging of protonated and deprotonated forms of carbonylcyanide p-trifluoromethoxy-phenylhydrazone (FCCP) molecules in live cells by Raman microscopy. Nitriles, structure-sensitive Raman tags, are used to detect the two distinct molecular structures, demonstrating the potential of Raman microscopy for structure-based imaging of bioactive small molecules.

UR - http://www.scopus.com/inward/record.url?scp=84892154213&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84892154213&partnerID=8YFLogxK

U2 - 10.1039/c3cc48587k

DO - 10.1039/c3cc48587k

M3 - Article

C2 - 24346645

AN - SCOPUS:84892154213

VL - 50

SP - 1341

EP - 1343

JO - Chemical Communications

JF - Chemical Communications

SN - 1359-7345

IS - 11

ER -

Simultaneous imaging of protonated and deprotonated carbonylcyanide p-trifluoromethoxyphenylhydrazone in live cells by Raman microscopy

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this