Simultaneous imaging of protonated and deprotonated carbonylcyanide p-trifluoromethoxyphenylhydrazone in live cells by Raman microscopy

Hiroyuki Yamakoshi; Almar F. Palonpon; Kosuke Dodo; Jun Ando; Satoshi S. Kawat; Katsumasa Fujita; Mikiko Sodeoka

doi:10.1039/c3cc48587k

Simultaneous imaging of protonated and deprotonated carbonylcyanide p-trifluoromethoxyphenylhydrazone in live cells by Raman microscopy

Hiroyuki Yamakoshi, Almar F. Palonpon, Kosuke Dodo, Jun Ando, Satoshi S. Kawat, Katsumasa Fujita, Mikiko Sodeoka

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

Abstract

We report the simultaneous imaging of protonated and deprotonated forms of carbonylcyanide p-trifluoromethoxy-phenylhydrazone (FCCP) molecules in live cells by Raman microscopy. Nitriles, structure-sensitive Raman tags, are used to detect the two distinct molecular structures, demonstrating the potential of Raman microscopy for structure-based imaging of bioactive small molecules.

Original language	English
Pages (from-to)	1341-1343
Number of pages	3
Journal	Chemical Communications
Volume	50
Issue number	11
DOIs	https://doi.org/10.1039/c3cc48587k
Publication status	Published - 2014 Jan 9
Externally published	Yes

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/c3cc48587k

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Simultaneous imaging of protonated and deprotonated carbonylcyanide p-trifluoromethoxyphenylhydrazone in live cells by Raman microscopy. / Yamakoshi, Hiroyuki; Palonpon, Almar F.; Dodo, Kosuke; Ando, Jun; Kawat, Satoshi S.; Fujita, Katsumasa; Sodeoka, Mikiko.

In: Chemical Communications, Vol. 50, No. 11, 09.01.2014, p. 1341-1343.

Research output: Contribution to journal › Article › peer-review

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AU - Dodo, Kosuke

AU - Ando, Jun

AU - Kawat, Satoshi S.

AU - Fujita, Katsumasa

AU - Sodeoka, Mikiko

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AB - We report the simultaneous imaging of protonated and deprotonated forms of carbonylcyanide p-trifluoromethoxy-phenylhydrazone (FCCP) molecules in live cells by Raman microscopy. Nitriles, structure-sensitive Raman tags, are used to detect the two distinct molecular structures, demonstrating the potential of Raman microscopy for structure-based imaging of bioactive small molecules.

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Simultaneous imaging of protonated and deprotonated carbonylcyanide p-trifluoromethoxyphenylhydrazone in live cells by Raman microscopy

Abstract

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