Simultaneous concentration of platelets and marrow cells: A simple and useful technique to obtain source cells and growth factors for regenerative medicine

Soh Nishimoto, Tomoki Oyama, Ken Matsuda

    Research output: Contribution to journalArticlepeer-review

    33 Citations (Scopus)

    Abstract

    Platelet-rich plasma (PRP) has attracted attention as a safe and cost-effective source of growth factors that stimulate cells to regenerate tissue. Bone marrow aspirate was processed with the same protocol to obtain PRP from peripheral blood. This concentrate contained condensed nucleated bone marrow cells, which are useful for regenerative medicine, as well as condensed platelets. In PRP derived from bone marrow aspirate, the density of platelets and levels of growth factors (platelet-derived growth factor and transforming growth factor-β) were the same as in PRP derived from peripheral blood. Condensation of nucleated cells, especially small-sized cells, was confirmed. With a simple and cost-effective technique, source cells and growth factors can be obtained at the same time. This simultaneous concentration of platelets and bone marrow cells has great potential as a source of materials for regenerative medicine.

    Original languageEnglish
    Pages (from-to)156-162
    Number of pages7
    JournalWound Repair and Regeneration
    Volume15
    Issue number1
    DOIs
    Publication statusPublished - 2007 Jan

    ASJC Scopus subject areas

    • Dermatology
    • Surgery

    Fingerprint Dive into the research topics of 'Simultaneous concentration of platelets and marrow cells: A simple and useful technique to obtain source cells and growth factors for regenerative medicine'. Together they form a unique fingerprint.

    Cite this