Simulation study on heart failure: effects of contractility on cardiac function

Hideyuki Honda, Kazuhiko Kinbara, Junji Tani, Tomohiko Ogimura, Yoshiro Koiwa, Tamotsu Takishima

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


Using the model proposed by Beyar and Sideman, the effect of maximum isometric active stress at optimal sarcomere length (σ0) on left ventricular (LV) function was examined. Comparing the results of calculated LV function with those of reported experiments, σ0 was shown to be a potential indicator of myocardial contractility, and the model of Beyar and Sideman successfully predicted LV function with various myocardial contractilities. The LVP compensation curve, which describes the relationship between σ0 and maximum LV pressure, was then hypothesized. The combination of the Beyar-Sideman model and the LVP compensation curve enabled the prediction and approximation of the actual process of deterioration in heart failure. These models represent a step towards a fundamentally new concept in the current clinical situation of compensated heart failure and also in evaluating the process of heart failure.

Original languageEnglish
Pages (from-to)39-46
Number of pages8
JournalMedical Engineering and Physics
Issue number1
Publication statusPublished - 1994


  • contractility
  • Heart
  • mathematical model
  • pump function

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Psychology(all)


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