Simulation study on effects of deformabilities of red blood cells on blood flow using particle method

Ken Ichi Tsubota, Shigeo Wada, Takami Yamaguchi

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

A computer simulation using particle method was carried out to investigate effects of deformabilities of red blood cells (RBCs) on blood flow in microcirculation. The motion of deformable RBCs was determined by the spring model on the basis of the minimum energy principle. The motion of the plasma fluid particles was analyzed by the moving-particle semi-implicit (MPS) method assuming incompressible viscous flow. The two-dimensional simulation of blood flow between parallel plates demonstrated that RBCs moved downstream and were deformed into a parachute shape as observed in experiments. Comparison between the results for single RBC and multiple RBCs clarified that the deformation of RBCs was suppressed by their neighboring RBCs. The higher the spring constants of the RBC model, the less deformed the RBCs were, causing large blood flow resistance. These results indicate that deformability of each RBC cooperates with mechanical interaction between RBCs in determining the rheological properties of blood on blood cellular scale.

Original languageEnglish
Pages (from-to)1483-1489
Number of pages7
JournalNihon Kikai Gakkai Ronbunshu, B Hen/Transactions of the Japan Society of Mechanical Engineers, Part B
Volume72
Issue number6
DOIs
Publication statusPublished - 2006 Jun

Keywords

  • Bio-Fluid Dynamics
  • Biomechanics
  • Blood
  • Blood Flow
  • Computational Fluid Dynamics (CFD)
  • Deformability
  • Particle Mechod
  • Red Blood Cells

ASJC Scopus subject areas

  • Condensed Matter Physics
  • Mechanical Engineering

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