Simulation Study of Noise Property of CMRO2 Quantitation Methods with Inhalation of 15O2

Nobuyuki Kudomi, Hiroshi Watabe, Yoshinori Miyake, Kyeong Min Kim, Miho Shidahara, Kouhei Hayashida, Hisashi Oka, Masayoshi Sagou, Yoshio Ishida, Takuya Hayashi, Hidehiro Iida

Research output: Contribution to conferencePaperpeer-review


Measurements of the oxygen consumption in brain have been studied by PET. Autoradiographic method (ARG) was suggested (Mintum et al.) to yield CMRO 2. This method required separately obtained information about CBF, CBV, thus time of 30-60 min. is required for three separate scans. To decrease the scan time, a new protocol was suggested as a rapid dual table method (ARG-D), in which [15O]water injection scan and [ 15O]O2 inhalation scan are continuously carried out. Another method of weighted integration(WI) method with single 3 min. 15O2 inhalation scan was suggested (Ohta et al.). We modified this method by taking into account the water re-circulation(WI-WR). In this study, the statistical noise properties and effects of error propagated from dispersion, delay, and volume of distribution on CMRO2 image, derived by these methods were evaluated. Tissue time activity curves was generated from typical blood time activity curves. A 80 % of noise at a peak in [15O] water tissue time acticity curve was added to study the noise propagation and accuracy in CMRO2 image. Also dispersion, delay, and volume of distribution was varied and evaluated the error propagation. Methods of ARG, WI-WR and ARG-D, reproduce the given CMRO2 within 2% accuracy, while method WI gives CMRO2 5-15 The effect of noise in unit of %SD was 12 % for ARG, 25 % for WI and WI-WR, and 17 % for ARG-D method. On the basis of simulation study suggests that the ARG-D method developed could be used to estimate the CMRO2 values in clinic.

Original languageEnglish
Number of pages2
Publication statusPublished - 2002
Externally publishedYes
Event2002 IEEE Nuclear Science Symposium Conference Record - Norfolk, VA, United States
Duration: 2002 Nov 102002 Nov 16


Other2002 IEEE Nuclear Science Symposium Conference Record
Country/TerritoryUnited States
CityNorfolk, VA

ASJC Scopus subject areas

  • Radiation
  • Nuclear and High Energy Physics
  • Radiology Nuclear Medicine and imaging


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