Simulation of shape transformations of lipid bilayer vesicles

Iteru Noguchi, Naohito Urakami, Masayuki Imai, Takashi Yamamoto

Research output: Contribution to journalArticlepeer-review

Abstract

Various shapes of vesicles, including sphere, prolate spheroid, oblate spheroid, and stomatocyte types, have been observed according to the osmotic difference between the inner and the outer vesicle. We investigated the process of vesicle deformation by carrying out dissipative particle dynamics simulations. With a decrease in the number of water particles in a vesicle, the transformations from sphere to prolate shape or oblate shape were observed. To investigate the mechanism of vesicle deformation in details, we carried out simulations by moving lipids between the inner and outer leaflets of the vesicle. As a result, the transforms between the prolate shape and the oblate shape could be observed. These results indicate that the shapes of vesicles are determined by the volume inside a vesicle and by the differences between the numbers of lipids forming the inner and outer leaflets of a vesicle. The result is in good agreement with the area difference elasticity model.

Original languageEnglish
Pages (from-to)605-610
Number of pages6
JournalKOBUNSHI RONBUNSHU
Volume67
Issue number10
DOIs
Publication statusPublished - 2010 Oct

Keywords

  • Area difference elasticity model
  • Biomembrane
  • Dissipative particle dynamics simulation
  • Vesicle deformation

ASJC Scopus subject areas

  • Chemical Engineering (miscellaneous)
  • Materials Science (miscellaneous)
  • Environmental Science(all)
  • Polymers and Plastics

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