Simplified PET measurement for evaluating histamine H 1 receptors in human brains using [ 11C]doxepin

Hideki Mochizuki; Yuichi Kimura; Kenji Ishii; Keiichi Oda; Toru Sasaki; Manabu Tashiro; Kazuhiko Yanai; Kiichi Ishiwata

doi:10.1016/j.nucmedbio.2004.06.009

Simplified PET measurement for evaluating histamine H ₁ receptors in human brains using [ ¹¹C]doxepin

Hideki Mochizuki, Yuichi Kimura, Kenji Ishii, Keiichi Oda, Toru Sasaki, Manabu Tashiro, Kazuhiko Yanai, Kiichi Ishiwata

Research output: Contribution to journal › Article

18 Citations (Scopus)

Abstract

The aim of this study was to develop simplified positron emission tomography measurement using [ ¹¹C]doxepin ([ ¹¹C]DOX) to evaluate histamine H ₁ receptors (H1Rs) in human brains. We evaluated the correlation between the distribution volume (DV) of [ ¹¹C]DOX, estimated quantitatively with a two-compartment model, and the [ ¹¹C]DOX uptake obtained at various time intervals and normalized using the metabolite-corrected plasma radioactivity. We found that the static 70- to 90-min images normalized using the plasma radioactivity at 10 min postinjection reflected the DV of [ ¹¹C]DOX-H1R binding.

Original language	English
Pages (from-to)	1005-1011
Number of pages	7
Journal	Nuclear Medicine and Biology
Volume	31
Issue number	8
DOIs	https://doi.org/10.1016/j.nucmedbio.2004.06.009
Publication status	Published - 2004 Nov 1

Keywords

Histamine H receptor
Static PET scanning
[ C]Doxepin

ASJC Scopus subject areas

Molecular Medicine
Radiology Nuclear Medicine and imaging
Cancer Research

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10.1016/j.nucmedbio.2004.06.009

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title = "Simplified PET measurement for evaluating histamine H 1 receptors in human brains using [ 11C]doxepin",

abstract = "The aim of this study was to develop simplified positron emission tomography measurement using [ 11C]doxepin ([ 11C]DOX) to evaluate histamine H 1 receptors (H1Rs) in human brains. We evaluated the correlation between the distribution volume (DV) of [ 11C]DOX, estimated quantitatively with a two-compartment model, and the [ 11C]DOX uptake obtained at various time intervals and normalized using the metabolite-corrected plasma radioactivity. We found that the static 70- to 90-min images normalized using the plasma radioactivity at 10 min postinjection reflected the DV of [ 11C]DOX-H1R binding.",

keywords = "Histamine H receptor, Static PET scanning, [ C]Doxepin",

author = "Hideki Mochizuki and Yuichi Kimura and Kenji Ishii and Keiichi Oda and Toru Sasaki and Manabu Tashiro and Kazuhiko Yanai and Kiichi Ishiwata",

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AU - Mochizuki, Hideki

AU - Kimura, Yuichi

AU - Ishii, Kenji

AU - Oda, Keiichi

AU - Sasaki, Toru

AU - Tashiro, Manabu

AU - Yanai, Kazuhiko

AU - Ishiwata, Kiichi

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