Simplified PET measurement for evaluating histamine H 1 receptors in human brains using [ 11C]doxepin

Hideki Mochizuki; Yuichi Kimura; Kenji Ishii; Keiichi Oda; Toru Sasaki; Manabu Tashiro; Kazuhiko Yanai; Kiichi Ishiwata

doi:10.1016/j.nucmedbio.2004.06.009

Simplified PET measurement for evaluating histamine H ₁ receptors in human brains using [ ¹¹C]doxepin

Hideki Mochizuki, Yuichi Kimura, Kenji Ishii, Keiichi Oda, Toru Sasaki, Manabu Tashiro, Kazuhiko Yanai, Kiichi Ishiwata

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

The aim of this study was to develop simplified positron emission tomography measurement using [ ¹¹C]doxepin ([ ¹¹C]DOX) to evaluate histamine H ₁ receptors (H1Rs) in human brains. We evaluated the correlation between the distribution volume (DV) of [ ¹¹C]DOX, estimated quantitatively with a two-compartment model, and the [ ¹¹C]DOX uptake obtained at various time intervals and normalized using the metabolite-corrected plasma radioactivity. We found that the static 70- to 90-min images normalized using the plasma radioactivity at 10 min postinjection reflected the DV of [ ¹¹C]DOX-H1R binding.

Original language	English
Pages (from-to)	1005-1011
Number of pages	7
Journal	Nuclear Medicine and Biology
Volume	31
Issue number	8
DOIs	https://doi.org/10.1016/j.nucmedbio.2004.06.009
Publication status	Published - 2004 Nov 1

Keywords

Histamine H receptor
Static PET scanning
[ C]Doxepin

ASJC Scopus subject areas

Molecular Medicine
Radiology Nuclear Medicine and imaging
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.nucmedbio.2004.06.009

Cite this

@article{2430f12ac65c402ebd154c73aa7a679d,

title = "Simplified PET measurement for evaluating histamine H 1 receptors in human brains using [ 11C]doxepin",

abstract = "The aim of this study was to develop simplified positron emission tomography measurement using [ 11C]doxepin ([ 11C]DOX) to evaluate histamine H 1 receptors (H1Rs) in human brains. We evaluated the correlation between the distribution volume (DV) of [ 11C]DOX, estimated quantitatively with a two-compartment model, and the [ 11C]DOX uptake obtained at various time intervals and normalized using the metabolite-corrected plasma radioactivity. We found that the static 70- to 90-min images normalized using the plasma radioactivity at 10 min postinjection reflected the DV of [ 11C]DOX-H1R binding.",

keywords = "Histamine H receptor, Static PET scanning, [ C]Doxepin",

author = "Hideki Mochizuki and Yuichi Kimura and Kenji Ishii and Keiichi Oda and Toru Sasaki and Manabu Tashiro and Kazuhiko Yanai and Kiichi Ishiwata",

year = "2004",

month = nov,

day = "1",

doi = "10.1016/j.nucmedbio.2004.06.009",

language = "English",

volume = "31",

pages = "1005--1011",

journal = "International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology",

issn = "0969-8051",

publisher = "Elsevier Inc.",

number = "8",

}

TY - JOUR

T1 - Simplified PET measurement for evaluating histamine H 1 receptors in human brains using [ 11C]doxepin

AU - Mochizuki, Hideki

AU - Kimura, Yuichi

AU - Ishii, Kenji

AU - Oda, Keiichi

AU - Sasaki, Toru

AU - Tashiro, Manabu

AU - Yanai, Kazuhiko

AU - Ishiwata, Kiichi

PY - 2004/11/1

Y1 - 2004/11/1

N2 - The aim of this study was to develop simplified positron emission tomography measurement using [ 11C]doxepin ([ 11C]DOX) to evaluate histamine H 1 receptors (H1Rs) in human brains. We evaluated the correlation between the distribution volume (DV) of [ 11C]DOX, estimated quantitatively with a two-compartment model, and the [ 11C]DOX uptake obtained at various time intervals and normalized using the metabolite-corrected plasma radioactivity. We found that the static 70- to 90-min images normalized using the plasma radioactivity at 10 min postinjection reflected the DV of [ 11C]DOX-H1R binding.

AB - The aim of this study was to develop simplified positron emission tomography measurement using [ 11C]doxepin ([ 11C]DOX) to evaluate histamine H 1 receptors (H1Rs) in human brains. We evaluated the correlation between the distribution volume (DV) of [ 11C]DOX, estimated quantitatively with a two-compartment model, and the [ 11C]DOX uptake obtained at various time intervals and normalized using the metabolite-corrected plasma radioactivity. We found that the static 70- to 90-min images normalized using the plasma radioactivity at 10 min postinjection reflected the DV of [ 11C]DOX-H1R binding.

KW - Histamine H receptor

KW - Static PET scanning

KW - [ C]Doxepin

UR - http://www.scopus.com/inward/record.url?scp=10644222781&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=10644222781&partnerID=8YFLogxK

U2 - 10.1016/j.nucmedbio.2004.06.009

DO - 10.1016/j.nucmedbio.2004.06.009

M3 - Article

C2 - 15607482

AN - SCOPUS:10644222781

VL - 31

SP - 1005

EP - 1011

JO - International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology

JF - International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology

SN - 0969-8051

IS - 8

ER -