TY - JOUR
T1 - Simplified PET measurement for evaluating histamine H 1 receptors in human brains using [ 11C]doxepin
AU - Mochizuki, Hideki
AU - Kimura, Yuichi
AU - Ishii, Kenji
AU - Oda, Keiichi
AU - Sasaki, Toru
AU - Tashiro, Manabu
AU - Yanai, Kazuhiko
AU - Ishiwata, Kiichi
PY - 2004/11/1
Y1 - 2004/11/1
N2 - The aim of this study was to develop simplified positron emission tomography measurement using [ 11C]doxepin ([ 11C]DOX) to evaluate histamine H 1 receptors (H1Rs) in human brains. We evaluated the correlation between the distribution volume (DV) of [ 11C]DOX, estimated quantitatively with a two-compartment model, and the [ 11C]DOX uptake obtained at various time intervals and normalized using the metabolite-corrected plasma radioactivity. We found that the static 70- to 90-min images normalized using the plasma radioactivity at 10 min postinjection reflected the DV of [ 11C]DOX-H1R binding.
AB - The aim of this study was to develop simplified positron emission tomography measurement using [ 11C]doxepin ([ 11C]DOX) to evaluate histamine H 1 receptors (H1Rs) in human brains. We evaluated the correlation between the distribution volume (DV) of [ 11C]DOX, estimated quantitatively with a two-compartment model, and the [ 11C]DOX uptake obtained at various time intervals and normalized using the metabolite-corrected plasma radioactivity. We found that the static 70- to 90-min images normalized using the plasma radioactivity at 10 min postinjection reflected the DV of [ 11C]DOX-H1R binding.
KW - Histamine H receptor
KW - Static PET scanning
KW - [ C]Doxepin
UR - http://www.scopus.com/inward/record.url?scp=10644222781&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=10644222781&partnerID=8YFLogxK
U2 - 10.1016/j.nucmedbio.2004.06.009
DO - 10.1016/j.nucmedbio.2004.06.009
M3 - Article
C2 - 15607482
AN - SCOPUS:10644222781
VL - 31
SP - 1005
EP - 1011
JO - International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology
JF - International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology
SN - 0969-8051
IS - 8
ER -