Simple synthesis of α-hydroxyamino carbonyl compounds: New scope of the nitroso aldol reaction

Norie Momiyama, Hisashi Yamamoto

Research output: Contribution to journalArticle

96 Citations (Scopus)

Abstract

(graph presented) The reaction of nitroso compounds with enolates, "the nitroso aldol reaction", occurs in high yield to generate α-hydroxyamino carbonyl compounds. Yields range from 42% to 98% with N-selectivity >99:1 from commercially available aromatic or aliphatic nitroso compounds and a variety of alkali metal or tin enolates.

Original languageEnglish
Pages (from-to)3579-3582
Number of pages4
JournalOrganic letters
Volume4
Issue number21
DOIs
Publication statusPublished - 2002 Oct 17

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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