Simple, chemoselective hydrogenation with thermodynamic stereocontrol

Kotaro Iwasaki, Kanny K. Wan, Alberto Oppedisano, Steven W.M. Crossley, Ryan A. Shenvi

Research output: Contribution to journalArticlepeer-review

183 Citations (Scopus)

Abstract

Few methods permit the hydrogenation of alkenes to a thermodynamically favored configuration when steric effects dictate the alternative trajectory of hydrogen delivery. Dissolving metal reduction achieves this control, but with extremely low functional group tolerance. Here we demonstrate a catalytic hydrogenation of alkenes that affords the thermodynamic alkane products with remarkably broad functional group compatibility and rapid reaction rates at standard temperature and pressure.

Original languageEnglish
Pages (from-to)1300-1303
Number of pages4
JournalJournal of the American Chemical Society
Volume136
Issue number4
DOIs
Publication statusPublished - 2014 Jan 29
Externally publishedYes

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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