Simple, chemoselective hydrogenation with thermodynamic stereocontrol

Kotaro Iwasaki, Kanny K. Wan, Alberto Oppedisano, Steven W.M. Crossley, Ryan A. Shenvi

    Research output: Contribution to journalArticlepeer-review

    141 Citations (Scopus)

    Abstract

    Few methods permit the hydrogenation of alkenes to a thermodynamically favored configuration when steric effects dictate the alternative trajectory of hydrogen delivery. Dissolving metal reduction achieves this control, but with extremely low functional group tolerance. Here we demonstrate a catalytic hydrogenation of alkenes that affords the thermodynamic alkane products with remarkably broad functional group compatibility and rapid reaction rates at standard temperature and pressure.

    Original languageEnglish
    Pages (from-to)1300-1303
    Number of pages4
    JournalJournal of the American Chemical Society
    Volume136
    Issue number4
    DOIs
    Publication statusPublished - 2014 Jan 29

    ASJC Scopus subject areas

    • Catalysis
    • Chemistry(all)
    • Biochemistry
    • Colloid and Surface Chemistry

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