Abstract
New two catalysts component system comprising of a primary β-amino silyl ethers as an organocatalyst and N-protected amino acids as a co-catalyst put together worked as an efficient organocatalyst system in the hetero Diels–Alder reaction of isatins with enones affording the chiral spirooxindole-tetrahydropyranones in good chemical yields and stereoselectivities (up to 94%, up to dr 78:22., up to 85% ee).
Original language | English |
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Pages (from-to) | 454-464 |
Number of pages | 11 |
Journal | Chirality |
Volume | 33 |
Issue number | 8 |
DOIs | |
Publication status | Published - 2021 Aug |
Keywords
- hetero Diels–Alder reaction
- organocatalysis
- spirooxindole
- β-amino alcohol
- β-amino silyl ether
ASJC Scopus subject areas
- Analytical Chemistry
- Catalysis
- Pharmacology
- Drug Discovery
- Spectroscopy
- Organic Chemistry