Silica gel-assisted preparation of (bromo)(chloro)(iodo)benzo[b]thiophenes bearing halogen atoms at the 2-, 4-, and 7-positions

Shinichi Mikami, Hiroki Tanaka, Hiroki Kishi, Shuhei Yoshida, Kozo Toyota

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

Six types of (bromo)(chloro)(iodo)benzo[b]thiophenes bearing halogen atoms at the 2-, 4-, and 7-positions were prepared from the corresponding 2-(1-adamantylsulfanyl)-1,4-dihalo-3-(haloethynyl)benzene derivatives, by treatment with silica gel under thermal conditions. 4,7-Dihalobenzo[b]thiophenes, bearing two different halogen atoms (chlorine, bromine, or iodine), were also prepared from 2-(1-adamantylsulfanyl)-3-(ethynyl)-1,4-dihalobenzene derivatives.

Original languageEnglish
Pages (from-to)1529-1548
Number of pages20
JournalHeterocycles
Volume96
Issue number9
DOIs
Publication statusPublished - 2018 Jan 1

ASJC Scopus subject areas

  • Analytical Chemistry
  • Pharmacology
  • Organic Chemistry

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