Silencing of the gene for homeobox protein HOXB13 by siRNA confers resistance to methylmercury on HEK293 cells

Gi Wook Hwang, Katsunori Ryoke, Tsutomu Takahashi, Akira Naganuma

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Methylmercury is an environmental pollutant that causes severe central nervous system disorders. We searched for transcription factors involved in the development of methylmercury toxicity and found that the decreased expression of a homeobox protein, HOXB13, in HEK293 cells conferred strong resistance to methylmercury.

Original languageEnglish
Pages (from-to)941-944
Number of pages4
JournalJournal of Toxicological Sciences
Volume35
Issue number6
DOIs
Publication statusPublished - 2010 Dec 1

Keywords

  • HOXB13
  • Homeobox protein
  • Methylmercury
  • Transcription factor

ASJC Scopus subject areas

  • Toxicology

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