Significant reduction of granulomas in nrf2-deficient mice infected with Mycobacterium tuberculosis

S. Mizuno, Masayuki Yamamoto, I. Sugawara

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

Objective: We have reported previously that mice deficient in nuclear erythroid 2 p45-related factor 2 (Nrf2), which regulates the expression of antioxidant and detoxification genes, showed significant susceptibility to airway inflammatory responses when exposed to diesel exhaust particles for eight weeks2. As disruption of Nrf2 promotes immune cells that stimulate Th2-like immunoresponsiveness, Nrf2-deficient mice may be resistant to M. tuberculosis infection. Setting: Nrf2-deficient mice were infected with M. tuberculosis aerially, and the size of their granulomas and cytokine mRNA expression were compared with those of wild-type mice. Results: Significant reduction of granuloma formation and tubercle bacilli in granulomas was noted in the deficient mice 27 weeks after infection, concurrently with higher expression of IL-2 and IL-13 mRNA. Conclusion: It is concluded that Nrf2 inversely regulates M. tuberculosis-induced granuloma development at the late stage.

Original languageEnglish
Pages (from-to)108-113
Number of pages6
JournalIndian Journal of Tuberculosis
Volume57
Issue number2
Publication statusPublished - 2010 Apr 1
Externally publishedYes

Keywords

  • C57bl/6 mouse
  • M. tuberculosis
  • Nrf2
  • Th2 cytokine

ASJC Scopus subject areas

  • Infectious Diseases

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