Significant association of coronary artery calcification in stent delivery route with restenosis after sirolimus-eluting stent implantation

Shumpei Mori, Satoshi Yasuda, Yu Kataoka, Isao Morii, Atsushi Kawamura, Shunichi Miyazaki

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)

Abstract

Background: Sirolimus-eluting stent (SES) has revolutionized interventional cardiology. Its application is spreading to complex, high-risk subsets of patients and lesions. Therefore, it is important to determine the factors associated with post-SES restenosis. Methods and Results: The study investigated 341 patients with angina pectoris, in whom SES was implanted. The coronary artery calcification (CAC) degree was assessed using the angiographic scoring system as follows: 0, none; 1, blocky or spotty calcification; 2, linear calcification compromising 1 side of the arterial lumen; 3, linear calcification found unidirectionally compromising both sides of the arterial lumen; 4, linear calcification found bidirectionally compromising both sides of the arterial lumen; and 5, blanket/circumferential and dense calcification. Restenosis was observed in 23 patients (7.3%). The target lesion (1.8±1.7 vs 0.7±1.1 [mean±SD]) and stent delivery route CAC scores (3.1±2.5 vs 1.4±2.0) were significantly higher in patients with restenosis than in those without it (P<0.0001). In multivariate analysis, the CAC score of the stent delivery route was independently associated with restenosis (odds ratio of 6.804, P<0.05), although CAC score of the target lesion was not. Conclusions: CAC in the stent delivery route is an important determinant of post-SES restenosis.

Original languageEnglish
Pages (from-to)1856-1863
Number of pages8
JournalCirculation Journal
Volume73
Issue number10
DOIs
Publication statusPublished - 2009 Oct

Keywords

  • Percutaneous coronary intervention
  • Restenosis
  • Sirolimus eluting stent

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Fingerprint

Dive into the research topics of 'Significant association of coronary artery calcification in stent delivery route with restenosis after sirolimus-eluting stent implantation'. Together they form a unique fingerprint.

Cite this