Significance of plasminogen-activation system in the formation of macroscopic types and invasion in esophageal carcinoma

Takuma Nomiya, Kenji Nemoto, Hideo Miyachi, Keisuke Fujimoto, Chiaki Takahashi, Ken Takeda, Haruo Matushita, Yoshihiro Ogawa, Yoshihiro Takai, Shogo Yamada

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

Background: The roles of urokinase-type plasminogen activator (uPA) and plasminogen activator inhibitor-1 (PAI-1) in the formation of macroscopic types and invasion were investigated. Materials and Methods: A total of 40 surgicallyresected esophageal carcinoma tissues were immunohistochemically stained, and the expression of uPA, PAI-1 and the uPA/PAI-1 ratio, were evaluated. Results: The expression of uPA was significantly stronger in the macroscopically infiltrative type (n=20: p=0.0027), whereas PAI-1 was significantly stronger in the localized type (n=20: p=0.0005). The uPA/PAI-1 ratio was significantly higher in the infiltrative type (p<0.0001). A significant correlation was found between the U/P ratio and the depth of tumor invasion (r=0.511, p=0.0014). Analysis of tumors of uniform size (4.0-6.0 cm in length), showed that the depth of invasion was significantly greater in the infiltrative type (p=0.0038). Conclusion: The results demonstrated that uPA and PAI-1 play important roles in invasion and formation of macroscopic types of esophageal carcinoma.

Original languageEnglish
Pages (from-to)2913-2916
Number of pages4
JournalAnticancer research
Volume22
Issue number5
Publication statusPublished - 2002 Sep

Keywords

  • Esophageal carcinoma
  • Invasion
  • Macroscopic findings
  • PAI-1
  • uPA

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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