TY - JOUR
T1 - Significance of levels of IL-6 and IL-8 after trauma
T2 - A study of 11 cytokines post-mortem using multiplex immunoassay
AU - Mimasaka, S.
AU - Funayama, Masato
AU - Hashiyada, M.
AU - Nata, M.
AU - Tsunenari, S.
PY - 2007/9/1
Y1 - 2007/9/1
N2 - Purpose: To identify cytokines useful for diagnosis of traumatic death. Methods: Post-mortem serum levels of 11 cytokines were assayed for 43 people who died of traumatic injury or from non-traumatic causes. Levels of granulocyte-macrophage colony stimulating factor, gamma interferon, interleukin IL-1β, IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, IL-13, and tumour necrosis factor-alpha were measured using multiplex immunoassay. Results: Levels of granulocyte-macrophage colony stimulating factor (p < 0.01), IL-6 (p < 0.001), and IL-8 (p < 0.01) among the traumatic group were significantly higher than those among the non-traumatic group. Anatomical trauma severity was also estimated using the total abbreviated injury scale and injury severity score, revealing significant positive correlations between the former and IL-6 (rs = 0.6523, p < 0.01) and IL-8 levels (rs = 0.6584, p < 0.01). Conclusions: Levels of IL-6 and IL-8 assist differentiation between traumatic and non-traumatic death, are useful objective indices of trauma severity and can support a diagnosis of traumatic death.
AB - Purpose: To identify cytokines useful for diagnosis of traumatic death. Methods: Post-mortem serum levels of 11 cytokines were assayed for 43 people who died of traumatic injury or from non-traumatic causes. Levels of granulocyte-macrophage colony stimulating factor, gamma interferon, interleukin IL-1β, IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, IL-13, and tumour necrosis factor-alpha were measured using multiplex immunoassay. Results: Levels of granulocyte-macrophage colony stimulating factor (p < 0.01), IL-6 (p < 0.001), and IL-8 (p < 0.01) among the traumatic group were significantly higher than those among the non-traumatic group. Anatomical trauma severity was also estimated using the total abbreviated injury scale and injury severity score, revealing significant positive correlations between the former and IL-6 (rs = 0.6523, p < 0.01) and IL-8 levels (rs = 0.6584, p < 0.01). Conclusions: Levels of IL-6 and IL-8 assist differentiation between traumatic and non-traumatic death, are useful objective indices of trauma severity and can support a diagnosis of traumatic death.
KW - AIS
KW - Cytokines
KW - Forensic pathology
KW - ISS
KW - Multiplex immunoassay
KW - Trauma severity
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U2 - 10.1016/j.injury.2007.02.045
DO - 10.1016/j.injury.2007.02.045
M3 - Article
C2 - 17574251
AN - SCOPUS:34547960393
VL - 38
SP - 1047
EP - 1051
JO - Injury
JF - Injury
SN - 0020-1383
IS - 9
ER -