Significance of defective endothelial signal transduction in impaired endothelium-dependent relaxation in atherosclerosis

Hiroaki Shimokawa, Ryuichi Nakaike, Akira Takeshita

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

The significance of the defective endothelial signal transduction in the impaired endothelium-dependent relaxations in atherosclerosis and related conditions was examined. Pertussis toxin-sensitive endothelium-dependent relaxations were prominently impaired in experimental atherosclerosis in pigs. The expression of endothelial Gi protein was reduced in atherosclerosis and related conditions in human coronary arteries. Thus, the dysfunction of pertussis toxin-sensitive G protein (Gi protein) may contribute to the impairment of the endothelium-dependent relaxations in atherosclerosis.

Original languageEnglish
Pages (from-to)28-33
Number of pages6
JournalGerontology
Volume41
DOIs
Publication statusPublished - 1995

Keywords

  • Atherosclerosis
  • Endothelium-dependent relaxation
  • Endothelium-derived relaxing factor
  • Gi protein
  • Nitric oxide

ASJC Scopus subject areas

  • Ageing
  • Geriatrics and Gerontology

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