Signaling pathways for stress responses and adaptation in Aspergillus species: Stress biology in the post-genomic era

Daisuke Hagiwara, Kazutoshi Sakamoto, Keietsu Abe, Katsuya Gomi

Research output: Contribution to journalReview article

20 Citations (Scopus)

Abstract

Aspergillus species are among the most important filamentous fungi in terms of industrial use and because of their pathogenic or toxin-producing features. The genomes of several Aspergillus species have become publicly available in this decade, and genomic analyses have contributed to an integrated understanding of fungal biology. Stress responses and adaptation mechanisms have been intensively investigated using the accessible genome infrastructure. Mitogen-activated protein kinase (MAPK) cascades have been highlighted as being fundamentally important in fungal adaptation to a wide range of stress conditions. Reverse genetics analyses have uncovered the roles of MAPK pathways in osmotic stress, cell wall stress, development, secondary metabolite production, and conidia stress resistance. This review summarizes the current knowledge on the stress biology of Aspergillus species, illuminating what we have learned from the genomic data in this "post-genomic era."

Original languageEnglish
Pages (from-to)1667-1680
Number of pages14
JournalBioscience, Biotechnology and Biochemistry
Volume80
Issue number9
DOIs
Publication statusPublished - 2016 Jan 1

Keywords

  • Aspergillus
  • MAPK pathway
  • Stress response
  • TCS system
  • Transcription factor

ASJC Scopus subject areas

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

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