TY - JOUR
T1 - Sialyllactose occurs as free lactones in ovine colostrum
AU - Nakamura, Tadashi
AU - Urashima, Tadasu
AU - Nakagawa, Miyuki
AU - Saito, Tadao
PY - 1998/8/24
Y1 - 1998/8/24
N2 - Three sialyl oligosaccharide fractions were separated from ovine colostrum by gel filtration, anion exchange chromatography and normal-phase HPLC. They were characterized by 1H-NMR spectrometry as follows: Neu5Acα2→3Galβ1→4Glc, Neu5Gcα2→6Galβ1→4Glc and three forms of Neu5Gcα2→3Galβ1→4Glc, namely Neu5Gcα2→3Galβ1→4Glc itself, its lactone derivative between the carboxyl group of Neu5Gc and Gal OH-2 and another lactone derivative between the carboxyl group and Gal OH-4. In this study, Neu5Gc-lactose lactones, in their free form, have been isolated for the first time from any natural sources including milk or colostrum. Copyright (C) 1998 Elsevier Science B.V.
AB - Three sialyl oligosaccharide fractions were separated from ovine colostrum by gel filtration, anion exchange chromatography and normal-phase HPLC. They were characterized by 1H-NMR spectrometry as follows: Neu5Acα2→3Galβ1→4Glc, Neu5Gcα2→6Galβ1→4Glc and three forms of Neu5Gcα2→3Galβ1→4Glc, namely Neu5Gcα2→3Galβ1→4Glc itself, its lactone derivative between the carboxyl group of Neu5Gc and Gal OH-2 and another lactone derivative between the carboxyl group and Gal OH-4. In this study, Neu5Gc-lactose lactones, in their free form, have been isolated for the first time from any natural sources including milk or colostrum. Copyright (C) 1998 Elsevier Science B.V.
KW - Colostrum
KW - Lactone
KW - Ovine
KW - Sialyllactose
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U2 - 10.1016/S0304-4165(98)00040-3
DO - 10.1016/S0304-4165(98)00040-3
M3 - Article
C2 - 9729433
AN - SCOPUS:0031840031
VL - 1381
SP - 286
EP - 292
JO - Biochimica et Biophysica Acta - General Subjects
JF - Biochimica et Biophysica Acta - General Subjects
SN - 0006-3002
IS - 3
ER -