Shortened telomere length in hepatocellular carcinomas and corresponding background liver tissues of patients infected with hepatitis virus

Kazuo Ohashi, Masahiro Tsutsumi, Kunihiko Kobitsu, Tomokazu Fukuda, Toshifumi Tsujiuchi, Eijiro Okajima, Saiho Ko, Yoshiyuki Nakajima, Hiroshige Nakano, Yoichi Konishi

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Abstract

The telomere length in 20 surgically resected human hepatocellular carcinomas (HCCs) and adjacent non-cancerous livers with hepatitis virus infection were investigated. All the HCC samples examined demonstrated shorter telomere length than the corresponding non-cancerous liver tissues, the respective average values being 5.4 kbp and 8.8 kbp (P < 0.001). The shortening of telomere length was most prominent in HCCs larger than 30 mm in diameter, and in both tumors and non-cancerous livers it was more marked with hepatitis B virus as compared with hepatitis C virus infection. These results indicate that telomere shortening is associated with not only progression, but also development of HCC, and there is a possible difference in the nature of the association in patients with hepatitis viruses of B and C types.

Original languageEnglish
Pages (from-to)419-422
Number of pages4
JournalJapanese Journal of Cancer Research
Volume87
Issue number5
DOIs
Publication statusPublished - 1996 May

Keywords

  • Hepatitis virus
  • Hepatocellular carcinoma
  • Telomere length

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Ohashi, K., Tsutsumi, M., Kobitsu, K., Fukuda, T., Tsujiuchi, T., Okajima, E., Ko, S., Nakajima, Y., Nakano, H., & Konishi, Y. (1996). Shortened telomere length in hepatocellular carcinomas and corresponding background liver tissues of patients infected with hepatitis virus. Japanese Journal of Cancer Research, 87(5), 419-422. https://doi.org/10.1111/j.1349-7006.1996.tb00239.x