Short tandem repeats in the human, cow, mouse, chicken, and lizard genomes are concentrated in the terminal regions of chromosomes

Kazuharu Misawa

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Repetitive sequences in a genome cause mapping errors, especially in the case of short reads, because of the presence of similar or identical sequences. Distribution of repetitive sequences in a genome must be studied to distinguish between mappable and unmappable regions. Previous studies showed that short tandem repeats (STRs) are clustered in the terminal regions of chromosomes in the human genome. It is an open question whether formation of STRs in the terminal regions of chromosomes occurs only in humans. The present study investigated the distribution of STRs in the human, cow, mouse, chicken, and lizard genomes. In this study, it was shown that STRs were concentrated in the terminal regions of chromosomes not only in the human genome, but also in the mouse, cow, chicken, and lizard genomes. The results suggested the mechanism through which STRs are shared by amniotes in which mammals, birds and lizards are included. Thus, we must be careful with the genomic sequences at chromosome ends of amniotes by using the next generation sequencers.

Original languageEnglish
Pages (from-to)280-285
Number of pages6
JournalGene Reports
Volume4
DOIs
Publication statusPublished - 2016 Sep 1

Keywords

  • Chromosome
  • Evolution
  • Mammalian genome
  • Next generation sequencer
  • Short tandem repeat

ASJC Scopus subject areas

  • Genetics

Fingerprint Dive into the research topics of 'Short tandem repeats in the human, cow, mouse, chicken, and lizard genomes are concentrated in the terminal regions of chromosomes'. Together they form a unique fingerprint.

Cite this