Short communication electroconvulsive shock regulates serotonin transporter mRNA expression in rat raphe nucleus

Haowei Shen, Yohtaro Numachi, Sumiko Yoshida, Shigenobu Toda, Shuichi Awata, Hiroo Matsuoka, Mitsumoto Sato

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

The antidepressive actions of electroconvulsive shock (ECS) therapy are considered to involve altered neurotransmission of serotonin. In this study, we investigated the effects of acute and chronic ECS on 5-hydroxytryptamine (5-HT) transporter mRNA expression in rat raphe nucleus. We found that serotonin transporter (5-HTT) mRNA expression was decreased in 9 and 24 h after acute ECS and in 3. 9. 24 h and 2 weeks after chronic ECS in rat raphe nucleus. We presume that the adaptive change in 5-HTT mRNA expression is possibly related to the therapeutic efficacy of electroconvulsive therapy (ECT) on medication-resistant depression.

Original languageEnglish
Pages (from-to)75-77
Number of pages3
JournalPsychiatry and Clinical Neurosciences
Volume55
Issue number1
DOIs
Publication statusPublished - 2001

Keywords

  • Electroconvulsive shock
  • Gene expression
  • Raphe nucleus
  • Serotonin transporter

ASJC Scopus subject areas

  • Neuroscience(all)
  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health

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