Shishihakuhito, a Kampo medicine for atopic dermatitis, suppresses NGF-induced neurite extension by inhibition of MEK/ERK signaling in PC12D cells

Koichiro Nakanishi, Ichiro Kawahata, Wen Sun, Yu Wang, Masaaki Yoshida, Yasushi Ohizumi, Tohru Yamakuni

Research output: Contribution to journalArticlepeer-review

Abstract

Accumulating evidence obtained from clinical studies as well as animal studies suggests that nerve growth factor (NGF) may play a crucial role in the pathogenic mechanism of atopic dermatitis (AD), involving severe scratching due to itching. Shishihakuhito is a Kampo medicine for AD. In the current study, we for the first time report that shishihakuhito extract has the activity to prevent NGF-induced stimulation of phoshorylation of MEK and ERK which has been demonstrated to mediate neurite outgrowth induced by this neurotrophic factor, and actually inhibit NGF-induced neurite extension in PC12D cells, a cellular model of peripheral sensory neurons. These findings suggest that shishihakuhito might prevent NGF signaling, thereby reducing the induction of severe itching and scratching in AD.

Original languageEnglish
Pages (from-to)16-21
Number of pages6
JournalJournal of Traditional Medicines
Volume28
Issue number1
DOIs
Publication statusPublished - 2011

Keywords

  • NGF-signaling
  • atopic dermatitis
  • shishihakuhito

ASJC Scopus subject areas

  • Drug Discovery
  • Complementary and alternative medicine

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