Sharing of the interleukin-2 (IL-2) receptor γ chain between receptors for IL-2 and IL-4

Motonari Kondo, Toshikazu Takeshita, Naoto Ishii, Masataka Nakamura, Sumiko Watanabe, Ken Ichi Arai, Kazuo Sugamura

Research output: Contribution to journalArticlepeer-review

718 Citations (Scopus)

Abstract

The γ chain of the interleukin-2 (IL-2) receptor is an indispensable subunit for IL-2 binding and intracellular signal transduction. A monoclonal antibody to the γ chain, TUGm2, inhibited IL-2 binding to the functional IL-2 receptors and also inhibited IL-4-induced cell growth and the high-affinity binding of IL-4 to the CTLL-2 mouse T cell line. Another monoclonal antibody, TUGm3, which reacted with the γ chain cross-linked with IL-2, also immunoprecipitated the γ chain when cross-linked with IL-4. These results suggest that the IL-2 receptor γ chain is functionally involved in the IL-4 receptor complex.

Original languageEnglish
Pages (from-to)1874-1877
Number of pages4
JournalScience
Volume262
Issue number5141
DOIs
Publication statusPublished - 1993

ASJC Scopus subject areas

  • General

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