Sharing of the IL-2 receptor γ chain with the functional IL-9 receptor complex

Yutaka Kimura, Toshikazu Takeshita, Motonari Kondo, Naoto Ishii, Masataka Nakamura, Jacques Van Snick, Kazuo Sugamura

Research output: Contribution to journalArticlepeer-review

189 Citations (Scopus)

Abstract

The third subunit, the so-called common γ (γc) chain, of the IL-2 receptor is shared among the receptors for IL-2, IL-4, IL-7 and IL-15, and dysfunction of the γc chain is thought to cause X-linked severe combined immunodeficiency (XSCID) ascribed to impairment of early T cell development. However, cytokines linked to XSCID are as yet unidentified. A mAb specific for the γc chain, TUGm2, profoundly inhibited cell proliferation in response to IL-9. Another mAb, TUGm3, immunoprecipltated [125I]IL-9 cross-linked with either the IL-9 receptor or the γc chain. These results demonstrate that the γc chain is included in the functional receptor complex for IL-9, which was initially characterized as a T cell growth factor and is essential for IL-9-dependent growth signal transductlon.

Original languageEnglish
Pages (from-to)115-120
Number of pages6
JournalInternational immunology
Volume7
Issue number1
DOIs
Publication statusPublished - 1995 Jan

Keywords

  • Anti-common γ chain mAb
  • Common γ chain
  • XSCID

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Fingerprint

Dive into the research topics of 'Sharing of the IL-2 receptor γ chain with the functional IL-9 receptor complex'. Together they form a unique fingerprint.

Cite this