Shared mushroom body circuits underlie visual and olfactory memories in Drosophila

Katrin Vogt, Christopher Schnaitmann, Kristina V. Dylla, Stephan Knapek, Yoshinori Aso, Gerald M. Rubin, Hiromu Tanimoto

    Research output: Contribution to journalArticle

    70 Citations (Scopus)

    Abstract

    In nature, animals form memories associating reward or punishment with stimuli from different sensory modalities, such as smells and colors. It is unclear, however, how distinct sensory memories are processed in the brain. We established appetitive and aversive visual learning assays for Drosophila that are comparable to the widely used olfactory learning assays. These assays share critical features, such as reinforcing stimuli (sugar reward and electric shock punishment), and allow direct comparison of the cellular requirements for visual and olfactory memories. We found that the same subsets of dopamine neurons drive formation of both sensory memories. Furthermore, distinct yet partially overlapping subsets of mushroom body intrinsic neurons are required for visual and olfactory memories. Thus, our results suggest that distinct sensory memories are processed in a common brain center. Such centralization of related brain functions is an economical design that avoids the repetition of similar circuit motifs.

    Original languageEnglish
    Article numbere02395
    Pages (from-to)e02395
    JournaleLife
    Volume3
    DOIs
    Publication statusPublished - 2014

    Keywords

    • associative memory
    • dopamine neurons
    • visual learning

    ASJC Scopus subject areas

    • Neuroscience(all)
    • Immunology and Microbiology(all)
    • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Vogt, K., Schnaitmann, C., Dylla, K. V., Knapek, S., Aso, Y., Rubin, G. M., & Tanimoto, H. (2014). Shared mushroom body circuits underlie visual and olfactory memories in Drosophila. eLife, 3, e02395. [e02395]. https://doi.org/10.7554/eLife.02395