Shape sensitivity on toxicity of gold nanoplates in breast cancer cells

Chunyan Wang, Yoshikazu Ito, Bindu Pradeep, Suresh Valiyaveettil

    Research output: Contribution to journalArticle

    2 Citations (Scopus)

    Abstract

    Gold nanomaterials (Au NMs) have been explored for a wide range of applications in catalysis and medicine. Here we report the shape sensitive toxicity of gold nanoplates (Au nanoplates) in breast cancer cell line, MCF7. Au nanoplates induced a dose- and shape-dependent toxicity to cancer cells. Oxidative stress induced by Au nanoplates is believed to be the trigger for the DNA, which resulted in cell apoptosis. In summary, the results from our study demonstrate that morphology appears to play a significant role in mediating the cellular responses and Au triangles nanoplates showed the highest toxicity to the cells. Such findings may be able to shine more light on the shape-dependent interaction between Au NMs and living organisms.

    Original languageEnglish
    Pages (from-to)9520-9530
    Number of pages11
    JournalJournal of Nanoscience and Nanotechnology
    Volume15
    Issue number12
    DOIs
    Publication statusPublished - 2015 Dec 1

    Keywords

    • Gold nanoplates
    • Hexagon
    • Pentagon
    • Shape-dependent toxicity
    • Triangles

    ASJC Scopus subject areas

    • Bioengineering
    • Chemistry(all)
    • Biomedical Engineering
    • Materials Science(all)
    • Condensed Matter Physics

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