Sexual function following radical prostatectomy: A prospective longitudinal study of cultural differences between Japanese and American men

S. Namiki, L. Kwan, M. Kagawa-Singer, T. Tochigi, N. Ioritani, A. Terai, Y. Arai, M. S. Litwin

Research output: Contribution to journalArticlepeer-review

31 Citations (Scopus)

Abstract

We conducted a cross-cultural comparison of the recovery of sexual function and bother during the first 2 years after radical prostatectomy (RP) between American and Japanese men. A total of 275 Japanese and 283 American men who underwent RP alone were prospectively enrolled into longitudinal cohort studies of health-related quality of life outcomes. Sexual function and bother (distress) were estimated with English and validated Japanese versions of the UCLA Prostate Cancer Index before RP and 1, 2-3, 4-6, 12, 18 and 24 months after RP. Each subject served as his own control. Japanese men reported lower sexual function scores at baseline, even after adjusted for age, prostate-specific antigen (PSA) and comorbidity (38 vs 61, P < 0.001). The two groups had similar baseline sexual bother (70 vs 69, P = 0.84). Japanese men had a smaller improvement in sexual function (β = 0.8 vs β = 5.3) and bother (β = 0.2 vs β = 2.9) over time than did the American men postoperatively, after adjusting for baseline score, age, baseline PSA and nerve-sparing. American men were more likely than Japanese men to regain their baseline sexual function by 24 months after surgery (hazard ratio (HR) = 1.60; 95% confidence interval (CI) = 1.06-2.42). In contrast, American men were less likely than Japanese men to return to baseline sexual bother (HR = 0.57; 95% CI = 0.44-0.75). This study demonstrates that Japanese and American men experience different patterns of recovery of their sexual function and bother after RP. Ethnicity may be a contributing factor.

Original languageEnglish
Pages (from-to)298-302
Number of pages5
JournalProstate Cancer and Prostatic Diseases
Volume11
Issue number3
DOIs
Publication statusPublished - 2008

ASJC Scopus subject areas

  • Oncology
  • Urology
  • Cancer Research

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