Sex steroid metabolism and actions in non-small cell lung carcinoma

Teeranut Asavasupreechar, Monica S.M. Chan, Ryoko Saito, Yasuhiro Miki, Viroj Boonyaratanakornkit, Hironobu Sasano

Research output: Contribution to journalReview articlepeer-review

2 Citations (Scopus)

Abstract

Despite recent development in targeted therapies, lung cancer still remains the leading cause of cancer death. Therefore, a better understanding of its pathogenesis and progression could contribute to improving the eventual clinical outcome of the patients. Results of recently published several in vitro and clinical studies indicated the possible involvement of sex steroids in both development and progression of non-small cell lung carcinoma (NSCLC). Therefore we summarized the reported clinical relevant information of the sex steroids, their receptors and steroid metabolizing enzymes related to NSCLC in this mini-review. In addition, we also reviewed the potential “endocrine therapy”, targeting sex steroid actions and/or metabolism in NSCLC patients.

Original languageEnglish
Article number105440
JournalJournal of Steroid Biochemistry and Molecular Biology
Volume193
DOIs
Publication statusPublished - 2019 Oct
Externally publishedYes

Keywords

  • Lung
  • Lung cancer treatment
  • Non-small cell lung carcinoma
  • Sex steroid receptors
  • Sex steroids

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Endocrinology
  • Clinical Biochemistry
  • Cell Biology

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