Sex and age-related differences in the urinary excretion of TXB2 in normal human subjects: A possible pathophysiological role of TXA2 in the aged kidney

Satoru Chiba, Keishi Abe, Kei Kudo, Ken Omata, Minoru Yasujima, Ko Sato, Masahide Seino, Yutaka Imai, Makito Sato, Kaoru Yoshinaga

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Urinary excretion of thromboxane B2 (TXB2), a stable metabolite of TXA2, was measured by radioimmunoassay in 58 mormal subjects (17 males and 41 females) aged from 19 to 98 years. The basal level of urinary TXB2 in normal subjects was 100±6.7 ng/day (mean±SEM). In young males, contamination of urine specimens with seminal fluid, which is known to contain large amounts of prostaglandin E, did not change the level of urinary TXB2. Urinary excretion of TXB2 was significantly higher in male subjects than in female (124±12.6 vs 90±7.4 ng/day, p<0.05). There was no significant age-related difference in 24-h urinary excretion of TXB2 in normal subjects. However, when urinary excretion of TXB2 was expressed as a function of urinary creatinine excretion, it was significantly higher in the elderly (60-93 years old) than in the younger subjects (19-59 years old) (141±15.7 vs 99±7.7 ng/g creatinine, p<0.02).Renal TXA2 may have a pathophysiological role in the functional impairment of the kidney in elderly people.

Original languageEnglish
Pages (from-to)347-358
Number of pages12
JournalProstaglandins, Leukotrienes and Medicine
Volume16
Issue number3
DOIs
Publication statusPublished - 1984 Dec
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Endocrinology

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