Severe postnatal cytomegalovirus infection in a very premature infant

Ritsuko Takahashi, Masato Tagawa, Masatoshi Sanjo, Hiroo Chiba, Takeshi Ito, Masaaki Yamada, Shingi Nakae, Akira Suzuki, Hidekazu Nishimura, Masako Naganuma, Norio Tominaga, Masako Moriuchi, Hiroyuki Moriuchi

Research output: Contribution to journalArticlepeer-review

31 Citations (Scopus)

Abstract

Several studies have reported that postnatally acquired cytomegalovirus (CMV) infection can cause sepsis-like syndrome in premature infants. We here report a 622-gram birth weight male infant of 23 weeks' gestation who had sepsis-like syndrome and pneumonia. Substantial CMV loads were detected in peripheral blood cells, plasma, and urine when the patient was in crisis, but was decreased in parallel to clinical improvement without using ganciclovir. CMV DNA was not detected from his umbilical cord or Guthrie card, even by highly sensitive real-time PCR. Molecular profiles were indistinguishable between the CMV strain isolated from his urine and that from maternal breast milk, indicating postnatal acquisition of CMV through breast milk. Although he had transient hearing impairment, his neurodevelopmental outcome of 30 months of corrected age was normal. Further accumulation of clinical and virological data in postnatal CMV infection is necessary for evaluating the severity and selecting patients requiring antiviral therapy.

Original languageEnglish
Pages (from-to)236-239
Number of pages4
JournalNeonatology
Volume92
Issue number4
DOIs
Publication statusPublished - 2007 Nov

Keywords

  • Breast milk
  • Ganciclovir
  • Hearing impairment
  • Viral load

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Developmental Biology

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