TY - JOUR
T1 - Severe epidemic myalgia with an elevated level of serum interleukin-6 caused by human parechovirus type 3
T2 - A case report and brief review of the literature
AU - Nakamura, Kiwamu
AU - Saito, Kyoichi
AU - Hara, Yasuka
AU - Aoyagi, Tetsuji
AU - Kitakawa, Kadzuhiro
AU - Abe, Yoshinobu
AU - Takemura, Hiromu
AU - Ikeda, Fumihito
AU - Kaku, Mitsuo
AU - Kanemitsu, Keiji
N1 - Publisher Copyright:
© 2018 The Author(s).
PY - 2018/8/7
Y1 - 2018/8/7
N2 - Background: Human parechovirus type 3 (HPeV-3) is known to cause cold-like symptoms, diarrhea, or severe infections such as sepsis in infants and children. In adults, HPeV-3 infection is rarely diagnosed because the symptoms are generally mild and self-limiting; however, this infection has been linked to epidemic myalgia, regardless of the presence of underlying diseases, immunosuppression, or sex. Case presentation: We describe an adult case of severe systemic myalgia and orchiodynia after infection with HPeV-3, which was transmitted from the child of the patient. Interleukin-6 (IL-6) level was found to be elevated in the patient's serum. Conclusion: Severe myalgia associated with HPeV-3 infection is potentially caused by an elevated serum level of IL-6.
AB - Background: Human parechovirus type 3 (HPeV-3) is known to cause cold-like symptoms, diarrhea, or severe infections such as sepsis in infants and children. In adults, HPeV-3 infection is rarely diagnosed because the symptoms are generally mild and self-limiting; however, this infection has been linked to epidemic myalgia, regardless of the presence of underlying diseases, immunosuppression, or sex. Case presentation: We describe an adult case of severe systemic myalgia and orchiodynia after infection with HPeV-3, which was transmitted from the child of the patient. Interleukin-6 (IL-6) level was found to be elevated in the patient's serum. Conclusion: Severe myalgia associated with HPeV-3 infection is potentially caused by an elevated serum level of IL-6.
KW - Epidemic myalgia
KW - Human parechovirus type 3
KW - IL-6
KW - Orchiodynia
UR - http://www.scopus.com/inward/record.url?scp=85054931868&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85054931868&partnerID=8YFLogxK
U2 - 10.1186/s12879-018-3284-5
DO - 10.1186/s12879-018-3284-5
M3 - Article
C2 - 30086720
AN - SCOPUS:85054931868
VL - 18
JO - BMC Infectious Diseases
JF - BMC Infectious Diseases
SN - 1471-2334
IS - 1
M1 - 381
ER -