Severe epidemic myalgia with an elevated level of serum interleukin-6 caused by human parechovirus type 3: A case report and brief review of the literature

Kiwamu Nakamura, Kyoichi Saito, Yasuka Hara, Tetsuji Aoyagi, Kadzuhiro Kitakawa, Yoshinobu Abe, Hiromu Takemura, Fumihito Ikeda, Mitsuo Kaku, Keiji Kanemitsu

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

Background: Human parechovirus type 3 (HPeV-3) is known to cause cold-like symptoms, diarrhea, or severe infections such as sepsis in infants and children. In adults, HPeV-3 infection is rarely diagnosed because the symptoms are generally mild and self-limiting; however, this infection has been linked to epidemic myalgia, regardless of the presence of underlying diseases, immunosuppression, or sex. Case presentation: We describe an adult case of severe systemic myalgia and orchiodynia after infection with HPeV-3, which was transmitted from the child of the patient. Interleukin-6 (IL-6) level was found to be elevated in the patient's serum. Conclusion: Severe myalgia associated with HPeV-3 infection is potentially caused by an elevated serum level of IL-6.

Original languageEnglish
Article number381
JournalBMC infectious diseases
Volume18
Issue number1
DOIs
Publication statusPublished - 2018 Aug 7

Keywords

  • Epidemic myalgia
  • Human parechovirus type 3
  • IL-6
  • Orchiodynia

ASJC Scopus subject areas

  • Infectious Diseases

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