Severe demyelination but no astrocytopathy in clinically definite neuromyelitis optica with anti-myelin-oligodendrocyte glycoprotein antibody

Kensuke Ikeda, Naoki Kiyota, Hiroshi Kuroda, Sato Douglas Kazutoshi, Shuhei Nishiyama, Toshiyuki Takahashi, Tatsuro Misu, Ichiro Nakashima, Kazuo Fujihara, Masashi Aoki

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

We report a patient with neuromyelitis optica (NMO) presenting anti-myelin-oligodendrocyte glycoprotein (MOG)-seropositive, in whom biomarkers of demyelination and astrocyte damage were measured during an acute attack. A 31-year-old man developed right optic neuritis followed by longitudinally extensive transverse myelitis, fulfilling the criteria for definite NMO. He was anti-MOG-seropositive and anti-Aquaporin-4 seronegative. The myelin basic protein level was markedly elevated whereas glial fibrillary acidic protein was not detectable in cerebrospinal fluid during an acute attack. His symptoms quickly improved after high-dose methylprednisolone therapy. This case suggests that NMO patients with anti-MOG may have severe demyelination in the absence of astrocyte injury.

Original languageEnglish
Pages (from-to)656-659
Number of pages4
JournalMultiple Sclerosis Journal
Volume21
Issue number5
DOIs
Publication statusPublished - 2015 Apr 1

Keywords

  • Neuromyelitis optica
  • aquaporin-4
  • glial fibrillary acidic protein
  • myelin basic protein
  • myelin-oligodendrocyte glycoprotein

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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