TY - JOUR
T1 - Severe demyelination but no astrocytopathy in clinically definite neuromyelitis optica with anti-myelin-oligodendrocyte glycoprotein antibody
AU - Ikeda, Kensuke
AU - Kiyota, Naoki
AU - Kuroda, Hiroshi
AU - Douglas Kazutoshi, Sato
AU - Nishiyama, Shuhei
AU - Takahashi, Toshiyuki
AU - Misu, Tatsuro
AU - Nakashima, Ichiro
AU - Fujihara, Kazuo
AU - Aoki, Masashi
N1 - Publisher Copyright:
© The Author(s), 2014.
PY - 2015/4/1
Y1 - 2015/4/1
N2 - We report a patient with neuromyelitis optica (NMO) presenting anti-myelin-oligodendrocyte glycoprotein (MOG)-seropositive, in whom biomarkers of demyelination and astrocyte damage were measured during an acute attack. A 31-year-old man developed right optic neuritis followed by longitudinally extensive transverse myelitis, fulfilling the criteria for definite NMO. He was anti-MOG-seropositive and anti-Aquaporin-4 seronegative. The myelin basic protein level was markedly elevated whereas glial fibrillary acidic protein was not detectable in cerebrospinal fluid during an acute attack. His symptoms quickly improved after high-dose methylprednisolone therapy. This case suggests that NMO patients with anti-MOG may have severe demyelination in the absence of astrocyte injury.
AB - We report a patient with neuromyelitis optica (NMO) presenting anti-myelin-oligodendrocyte glycoprotein (MOG)-seropositive, in whom biomarkers of demyelination and astrocyte damage were measured during an acute attack. A 31-year-old man developed right optic neuritis followed by longitudinally extensive transverse myelitis, fulfilling the criteria for definite NMO. He was anti-MOG-seropositive and anti-Aquaporin-4 seronegative. The myelin basic protein level was markedly elevated whereas glial fibrillary acidic protein was not detectable in cerebrospinal fluid during an acute attack. His symptoms quickly improved after high-dose methylprednisolone therapy. This case suggests that NMO patients with anti-MOG may have severe demyelination in the absence of astrocyte injury.
KW - Neuromyelitis optica
KW - aquaporin-4
KW - glial fibrillary acidic protein
KW - myelin basic protein
KW - myelin-oligodendrocyte glycoprotein
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U2 - 10.1177/1352458514551455
DO - 10.1177/1352458514551455
M3 - Article
C2 - 25257613
AN - SCOPUS:84952794298
VL - 21
SP - 656
EP - 659
JO - Multiple Sclerosis Journal
JF - Multiple Sclerosis Journal
SN - 1352-4585
IS - 5
ER -