Severe autoimmune hemolytic anemia after ABO match living donor liver transplantation

Katsura Kohata, Tohru Fujiwarw, Joji Yamamoto, Minami Yamada, Kenichi Ishizawa, Kazushige Satoh, Satoshi Sekiguchi, Junichi Kameoka, Susumu Satomi, Hideo Harigae

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

A case of severe autoimmune hemolytic anemia after ABO matched living donor liver transplantation. We present here a case of severe autoimmune hemolytic anemia after ABO matched living donor liver transplantation. The patient is 56 y.o male. He received living donor liver transplantation from his ABO matched son in May 2007. In July, he was suffered from a progressive anemia, and diagnosed as autoimmune hemolytic anemia by the laboratory examinations. Intensive treatment including predonisolone, azathiopurine, rituximab, plasma exchange, was given, however, the disease was resistant to the treatment. By the administration of cyclophosphamide combined with rituximab, remission was finally achieved. To date, immune mediated hemolytic anemia after ABO matched living donor liver transplantation has not been reported, although several cases of ABO mismatched living donor liver transplantation have been reported. His severe but transient clinical course of anemia suggests that the transient emergence of donor lymphocytes may be responsible for onset of hemolytic anemia.

Original languageEnglish
Pages (from-to)20-23
Number of pages4
JournalJapanese Journal of Clinical Immunology
Volume33
Issue number1
DOIs
Publication statusPublished - 2010 Mar 5

Keywords

  • Hemolytic anemia
  • Liver transplant

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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