Severe Acute Exacerbation in Chronic Hepatitis B Virus Infection in Sendai, Japan

Atsushi Kanno, Hiroshi Suzuki, Yutaka Miyazaki, Schuichi Sato, Masao Otsuki, Yoshio Goto, Hitoshi Ohori

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4 Citations (Scopus)


In order to examine the clinical features of severe acute exacerbation in chronic hepatitis B virus (HBV) infection, 297 hepatitis B surface antigen (HBsAg) carriers were followed for 35±22 months (mean±S.D.) in Tohoku University Hospital from 1976 to 1987. Of these, 10 experienced severe acute exacerbation with hepatic decompensation. All of these patients had intense subjective symptoms related to the hepatitis. They were all icteric and 8 had ascites. Three developed to fulminant hepatic failure, eventually died. Histology after the exacerbation showed severe hepatic damage such as massive hepatic necrosis and bridging hepatic necrosis in a half of them. Six cases were suspected to result from spontaneous reactivation and 2 from drug-induced reactivation of chronic HBV infection, and the other 2 from superinfection with non-A, non-B hepatitis agent (s). These results suggest that the reactivation of chronic HBV infection is an important factor of severe acute exacerbations in chronic HBV infection in Japan.

Original languageEnglish
Pages (from-to)363-371
Number of pages9
Journalthe tohoku journal of experimental medicine
Issue number4
Publication statusPublished - 1988
Externally publishedYes


  • HBsAg carrier
  • reactivation of chronic HBV infection
  • severe acute exacerbation

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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