Serum selenium predicts achievement of full-dose cisplatin in concurrent chemoradiotherapy for locally advanced head and neck squamous cell carcinoma: A prospective, observational study

Akira Ohkoshi, Ryo Ishii, Shun Wakamori, Yuki Nakayama, Takuya Yoshida, Kenjiro Higashi, Ayako Nakanome, Takenori Ogawa, Yukio Katori

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: Concurrent chemoradiotherapy (CCRT) with three-weekly high-dose cisplatin (100 mg/m2) is a standard treatment for locally advanced head and neck squamous cell carcinoma (HNSCC), but compliance with cisplatin is often poor due to various adverse events. The aim of this prospective, observational study was to determine the predictors of achievement of full-dose cisplatin. Methods: A prospective, observational study was conducted involving 60 patients who received CCRT with three-weekly high-dose cisplatin (100 mg/m2) for locally advanced HNSCC. Possible predictors affecting compliance with cisplatin were subjected to univariate and multivariate logistic regression analyses. Age, sex, primary site, clinical stage, treatment intent, history of hypertension, diabetes mellitus, smoking and drinking habits, body mass index, creatinine clearance, serum albumin, controlling nutrition status, trace elements (Fe, Zn, Cu, Se), acute kidney injury, white blood cell count decrease, neutrophilia, and weight loss were the variables evaluated. Results: Twenty-seven patients achieved full-dose cisplatin (300 mg/m2), and the other 33 patients did not. Multivariate logistic regression analysis showed that both mild renal dysfunction and selenium deficiency before treatment independently had negative impacts on achievement of full-dose cisplatin. Conclusions: As well as renal function, selenium deficiency is a potential therapeutic target for CCRT with high-dose cisplatin in HNSCC patients.

Original languageEnglish
Article number105475
JournalOral Oncology
Volume121
DOIs
Publication statusPublished - 2021 Oct
Externally publishedYes

Keywords

  • Cisplatin
  • Concurrent chemoradiotherapy
  • Head and neck cancer
  • Renal insufficiency
  • Selenium
  • Trace elements

ASJC Scopus subject areas

  • Oral Surgery
  • Oncology
  • Cancer Research

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