Serum levels of stem cell factor and thrombopoietin are markedly decreased in fulminant hepatic failure patients with a poor prognosis

Kazuo Okumoto, Takafumi Saito, Motoyuki Onodera, Ayuka Sakamoto, Mamiko Tanaka, Etsuko Hattori, Hiroaki Haga, Jun Itsu Ito, Kazuhiko Sugahara, Koji Saito, Hitoshi Togashi, Sumio Kawata

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12 Citations (Scopus)

Abstract

Background and Aim: Hematopoietic growth factors including stem cell factor (SCF), thrombopoietin (TPO) and granulocyte colony stimulating factor (G-CSF) have a potential role in inducing bone marrow hematopoietic stem cells to move into the circulation, and the association of these factors with liver regeneration has received a lot of attention recently. The aim of this study was to determine the serum levels of such factors in patients with acute liver injury. Methods: The subjects were 25 patients with acute hepatitis (AH) who had a favorable prognosis and 26 patients with fulminant hepatitis (FH), of whom 11 were alive and 15 had died. Sixty-six healthy subjects matched for age and sex served as controls. Serum samples were collected before treatment, and the levels of SCF, TPO and G-CSF were measured using enzyme-linked immunosorbant assays. Results: The levels of SCF and TPO were significantly lower in FH patients than in AH patients and the controls, and were also significantly lower in the FH patients who died, compared to the surviving patients. The G-CSF levels did not differ among them. Conclusions: These results suggest that low serum levels of SCF and TPO may be linked to poor prognosis in patients with severe liver injury.

Original languageEnglish
Pages (from-to)1265-1270
Number of pages6
JournalJournal of Gastroenterology and Hepatology (Australia)
Volume22
Issue number8
DOIs
Publication statusPublished - 2007 Aug

Keywords

  • Bone marrow
  • Fulminant hepatitis
  • Growth factor
  • Liver regeneration
  • Stem cell

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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    Okumoto, K., Saito, T., Onodera, M., Sakamoto, A., Tanaka, M., Hattori, E., Haga, H., Ito, J. I., Sugahara, K., Saito, K., Togashi, H., & Kawata, S. (2007). Serum levels of stem cell factor and thrombopoietin are markedly decreased in fulminant hepatic failure patients with a poor prognosis. Journal of Gastroenterology and Hepatology (Australia), 22(8), 1265-1270. https://doi.org/10.1111/j.1440-1746.2006.04497.x