Serum leptin levels are associated with hyperinsulinemia independent of body mass index but not with visceral obesity

Hoon Kim-Motoyama, Takuhiro Yamaguchi, Tomiyoshi Katakura, Masakazu Miura, Yasuo Ohashi, Yoshio Yazaki, Takashi Kadawaki

Research output: Contribution to journalArticlepeer-review

31 Citations (Scopus)

Abstract

To examine the relationship between leptin levels and visceral obesity or plasma insulin levels, we studied serum leptin levels, fat distribution assessed by CT scan, and plasma insulin levels during 75 g oral glucose load in 100 Japanese men. Regression analysis adjusted by age and body mass index (BMI) showed leptin levels to be associated with visceral fat area(V)(p = 0.003), subcutaneous fat area(S)(p < 0.0001), and V + S(p < 0.0001), but not with V/S ratio(p = 0.897). By regression analysis adjusted by age, BMI, and V + S, serum leptin levels were still highly and positively correlated with plasma insulin levels during 75 g oral glucose load (p < 0.001), insulin resistance index(p < 0.001), and p cell function index(p = 0.009) in homeostasis model assessment. These data suggest that hyperinsulinemia, but not visceral obesity, may be regulators of serum leptin levels independent of BMI.

Original languageEnglish
Pages (from-to)340-344
Number of pages5
JournalBiochemical and biophysical research communications
Volume239
Issue number1
DOIs
Publication statusPublished - 1997 Oct 9
Externally publishedYes

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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