Serum insulinlike growth factor-I in biliary atresia

Shigehiko Yoshida, Masaki Nio, Yutaka Hayashi, Ryoji Ohi, Ikuo Kawamura, Toshio Goto

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Background/Purpose: Low level of Insulinlike growth factor-I (IGF-I) has been reported in children with chronic liver disease like biliary atresia (BA) awaiting liver transplantation. However, there has been no report on IGF-I in BA managed without liver transplantation. Methods: The authors measured IGF-I and growth hormone (GH) in 21 postoperative BA, and 17 choledochal cysts (CC) as a control with normal liver function. To avoid an influence of aging, IGF-I was analyzed after converting them into a newly defined index "IGF%." IGF% is proportional to the lower limit of the value of IGF-I in gender- and age-matched normal control previously reported in literature. Results: IGF% in BA was significantly lower than that in CC. IGF% tended to be lower in Kasai's type III (atresia at the porta hepatis) and higher in the jaundice-free group. IGF% in patients with esophageal varices was significantly lower, The correlation between choline esterase and IGF% was positive and that for TTT and IGF% was negative. Conclusions: Low level of IGF-I is a characteristic finding in BA, especially in patients without need of liver transplantation. And it may reflect the severity of pathologic changes (ie, hepatic fibrosis and reduced volume of normally functioning liver) in BA liver.

Original languageEnglish
Pages (from-to)211-215
Number of pages5
JournalJournal of Pediatric Surgery
Volume38
Issue number2
DOIs
Publication statusPublished - 2003 Feb 1

Keywords

  • Biliary atresia
  • Insulinlike growth factor-I

ASJC Scopus subject areas

  • Surgery
  • Pediatrics, Perinatology, and Child Health

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    Yoshida, S., Nio, M., Hayashi, Y., Ohi, R., Kawamura, I., & Goto, T. (2003). Serum insulinlike growth factor-I in biliary atresia. Journal of Pediatric Surgery, 38(2), 211-215. https://doi.org/10.1053/jpsu.2003.50045