Serum fluoride concentration after sevoflurane anesthesia in ethanol treated rats: Special reference to cytochrome P-450 in the liver

Eiji Masaki, Tsutomu Kondou, Junichi Hirakawa, Masahiro Kawamura, Yoshikiyo Amaki

Research output: Contribution to journalArticlepeer-review

Abstract

The relationship between serum concentration of inorganic fluoride (F -) and cytochrome P-450 content after sevoflurane anesthesia was investigated in ethanol treated rats. Twenty male Wistar rats were randomly divided into 2 isocaloric diet groups of 10 rats each: one group receiving a standard diet and the other an ethanol diet. After 28 days on the diets the animals were administered 2.5% sevoflurane for 2 hr with 30% oxygen and 70% nitrous oxide. Cytochrome P-450 and cytochrome b-, were induced by the ethanol diet. In the ethanol diet group serum concentration of F - was significantly higher than that of the standard diet group after sevoflurane anesthesia. These results suggest that cytochrome P-450 and b 5, which were induced by ethanol, enhanced sevoflurane defluorination.

Original languageEnglish
Pages (from-to)426-432
Number of pages7
JournalJournal of Anesthesia
Volume6
Issue number4
DOIs
Publication statusPublished - 1992 Oct 1

Keywords

  • cytochrome P-450
  • cytochrome b
  • ethanol inorganic fluoride
  • sevoflurane

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

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