The relationship between serum concentration of inorganic fluoride (F -) and cytochrome P-450 content after sevoflurane anesthesia was investigated in ethanol treated rats. Twenty male Wistar rats were randomly divided into 2 isocaloric diet groups of 10 rats each: one group receiving a standard diet and the other an ethanol diet. After 28 days on the diets the animals were administered 2.5% sevoflurane for 2 hr with 30% oxygen and 70% nitrous oxide. Cytochrome P-450 and cytochrome b-, were induced by the ethanol diet. In the ethanol diet group serum concentration of F - was significantly higher than that of the standard diet group after sevoflurane anesthesia. These results suggest that cytochrome P-450 and b 5, which were induced by ethanol, enhanced sevoflurane defluorination.
- cytochrome P-450
- cytochrome b
- ethanol inorganic fluoride
ASJC Scopus subject areas
- Anesthesiology and Pain Medicine