TY - JOUR
T1 - Serum biological antioxidant potential predicts the prognosis of hemodialysis patients
AU - Ishii, Tomoko
AU - Ohtake, Takayasu
AU - Okamoto, Koji
AU - Mochida, Yasuhiro
AU - Ishioka, Kunihiro
AU - Oka, MacHiko
AU - Maesato, Kyoko
AU - Ikee, Ryota
AU - Moriya, Hidekazu
AU - Hidaka, Sumi
AU - Doi, Kent
AU - Noiri, Eisei
AU - Fujita, Toshiro
AU - Kobayashi, Shuzo
PY - 2011/2
Y1 - 2011/2
N2 - Background: It is well known that oxidative stress is enhanced in patients with end-stage renal disease. However, little is known about the relationship between serum antioxidant capacity and clinical outcome in hemodialysis (HD) patients. Methods: We examined the relationship between serum biomarkers of oxidative stress and clinical outcomes including all-cause mortality, hospitalization rate and incidence of cardiovascular events in HD patients. As biomarkers of oxidative stress, we measured serum levels of coenzyme Q10 (CoQ10) and biological antioxidant potential (BAP). Results: 108 patients were observed for 30 months as the follow-up periods. The survival group (n = 83) showed significantly higher BAP values compared with those in death groups (n = 25; p < 0.05). When serum BAP levels were divided into two groups by their median value, the group with higher BAP values had a better survival rate than that with lower BAP values on the Kaplan-Meier survival analysis (p = 0.05). Although serum levels of CoQ10 did not show any association with clinical outcomes, lower BAP was selected as an independent risk factor for all-cause mortality as well as the absence of angiotensin-converting enzyme inhibitors/angiotensin II receptor blockers therapy by age-adjusted Cox regression analysis. Conclusions: This study indicated that BAP could predict the prognosis of HD patients.
AB - Background: It is well known that oxidative stress is enhanced in patients with end-stage renal disease. However, little is known about the relationship between serum antioxidant capacity and clinical outcome in hemodialysis (HD) patients. Methods: We examined the relationship between serum biomarkers of oxidative stress and clinical outcomes including all-cause mortality, hospitalization rate and incidence of cardiovascular events in HD patients. As biomarkers of oxidative stress, we measured serum levels of coenzyme Q10 (CoQ10) and biological antioxidant potential (BAP). Results: 108 patients were observed for 30 months as the follow-up periods. The survival group (n = 83) showed significantly higher BAP values compared with those in death groups (n = 25; p < 0.05). When serum BAP levels were divided into two groups by their median value, the group with higher BAP values had a better survival rate than that with lower BAP values on the Kaplan-Meier survival analysis (p = 0.05). Although serum levels of CoQ10 did not show any association with clinical outcomes, lower BAP was selected as an independent risk factor for all-cause mortality as well as the absence of angiotensin-converting enzyme inhibitors/angiotensin II receptor blockers therapy by age-adjusted Cox regression analysis. Conclusions: This study indicated that BAP could predict the prognosis of HD patients.
KW - Angiotensin-converting enzyme inhibitors/angiotensin II receptor blockers
KW - Antioxidant
KW - Biological antioxidant potential BAP
KW - Hemodialysis patients
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U2 - 10.1159/000320201
DO - 10.1159/000320201
M3 - Article
C2 - 20805696
AN - SCOPUS:77956071094
VL - 117
SP - c230-c236
JO - Nephron - Clinical Practice
JF - Nephron - Clinical Practice
SN - 1660-2110
IS - 3
ER -