Serum albumin-treated sn-38 prodrug nanoparticles toward cancer treatment

Research output: Contribution to journalArticlepeer-review

Abstract

Carrier-free drug nanoparticles are emerging as a next generation of drug delivery systems. Herein, we worked on improving their dispersion stability in the physiological environment by employing serum albumin protein. With anticancer SN-38 prodrug nanoparticles (NPs) and bovine serum albumin (BSA) as model studies, it was found that BSA prevented SN-38 NPs from aggregating in phosphate buffered saline, and the resulted nanoparticle dispersion becomes stable while maintains their anticancer efficiency.

Original languageEnglish
Pages (from-to)1555-1558
Number of pages4
JournalChemistry Letters
Volume50
Issue number8
DOIs
Publication statusPublished - 2021 Aug

Keywords

  • Dispersion stability
  • Prodrug nanoparticles
  • Serum albumin

ASJC Scopus subject areas

  • Chemistry(all)

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