Serum adiponectin level as an independent predictor of mortality in patients with congestive heart failure

Toshihiro Tamura, Yutaka Furukawa, Ryoji Taniguchi, Yukihito Sato, Koh Ono, Hisanori Horiuchi, Yoshihisa Nakagawa, Toru Kita, Takeshi Kimura

Research output: Contribution to journalArticlepeer-review

84 Citations (Scopus)

Abstract

Background: Congestive heart failure (CHF) is associated with altered energy homeostasis and myocardial inflammation, hypertrophy, and fibrosis. Adiponectin, an insulin-sensitizing adipocytokine, may affect these pathogenic factors, and the circulating adiponectin level may serve as a biological marker of CHF. This study aimed to assess the significance of serum adiponectin as a prognostic marker for Japanese CHF patients. Methods and Results: The serum adiponectin levels were compared between 54 (24 ischemic and 30 non-ischemic) CHF patients with left ventricular systolic dysfunction and 55 age- and gender-matched control subjects. The CHF patients also underwent simultaneous clinical assessment and measurements for brain natriuretic peptide (BNP) and parameters of lipid or glucose metabolism. Compared with the controls, the CHF patients showed significantly increased serum adiponectin levels [6.7 (4.9-12.6) vs 14.6 (9.7-25.4) μg/ml, p<0.0001]. In the CHF patients, the log-transformed values of the serum adiponectin levels positively correlated with the log-transformed values of the plasma BNP levels (p=0.0003, r=0.48) and inversely correlated with the body mass index (p=0.0006, r=-0.46). Furthermore, an increase in the serum adiponectin level was associated with higher mortality (p<0.05), particularly in the ischemic CHF patients (p<0.005). Conclusions: An increase in the circulating adiponectin level was associated with higher mortality in the ischemic CHF patients. Adiponectin may be an informative risk marker for Japanese CHF patients.

Original languageEnglish
Pages (from-to)623-630
Number of pages8
JournalCirculation Journal
Volume71
Issue number5
DOIs
Publication statusPublished - 2007

Keywords

  • Adiponectin
  • Brain natriuretic peptide
  • Congestive heart failure
  • Mortality

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'Serum adiponectin level as an independent predictor of mortality in patients with congestive heart failure'. Together they form a unique fingerprint.

Cite this