TY - JOUR
T1 - Serum 25-hydroxyvitamin D level as an independent determinant of quality of life in osteoporosis with a high risk for fracture
AU - Ohta, Hiroaki
AU - Uemura, Yukari
AU - Nakamura, Toshitaka
AU - Fukunaga, Masao
AU - Ohashi, Yasuo
AU - Hosoi, Takayuki
AU - Mori, Satoshi
AU - Sugimoto, Toshitsugu
AU - Itoi, Eiji
AU - Orimo, Hajime
AU - Shiraki, Masataka
N1 - Funding Information:
The JOINT study was sponsored by the Public Health Research Foundation (PHRF). PHRF have received financial support from Japan Arteriosclerosis Prevention Fund, Teijin Pharma Ltd, Asahi Kasei Corporation, Takeda Pharmaceutical Company Ltd, GE Healthcare Japan, Toyo Medic Company Ltd, Banyu Pharmaceutical Company Ltd, and Dainippon Sumitomo Pharma Company Ltd. The authors have indicated that they have no other conflicts of interest with regard to the content of this article.
Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 2014/2/1
Y1 - 2014/2/1
N2 - Background Deteriorated quality of life (QOL) is a major problem in osteoporotic women. However, little is known regarding the determinants of QOL in patients with osteoporosis. Objective Our aim was to explore the role of vitamin D status on QOL score in osteoporosis with high fracture risk. Methods Patients were osteoporotic women aged ≥70 years and with ≥1 risk factor for incident fracture, namely prevalent osteoporotic fracture, bone mineral density (BMD) >-3.0 SD of young adult mean, or high bone turnover marker. Health-related QOL was assessed using the Japanese Osteoporosis Quality of Life Questionnaire (JOQOL). When patients were classified into quartiles by total QOL score). Serum 25-hydroxyvitamin D (25[OH]D) level was measured by immunoassay. Results A total of 1585 osteoporotic women were included in the study (age range, 70-95 years). Age, body mass index, serum 25(OH)D status (low, normal, or high), bone mineral density, number of prevalent vertebral fractures, presence of hypertension, presence of osteoarthritis, and history of falls were significantly correlated with QOL quartile. Multivariate liner regression analysis indicated that low serum 25(OH)D level (<20 ng/mL) was an independent determinant of total QOL score quartile (P = 0.0055). The conventional determinants of QOL - age (P < 0.0001), body mass index (P = 0.0060), number of prevalent vertebral fractures (P < 0.0001), presence of osteoarthritis (P = 0.0074), and history of fall (P = 0.0098) - were also independent determinants of total QOL score. Conclusions These results strongly suggest that low serum 25(OH)D level was a significant determinant of QOL in these osteoporotic women, independently of the conventional factors that reduce QOL. Maintenance of serum 25(OH)D levels >20 ng/mL may be required to maintain patients' QOL in osteoporosis.
AB - Background Deteriorated quality of life (QOL) is a major problem in osteoporotic women. However, little is known regarding the determinants of QOL in patients with osteoporosis. Objective Our aim was to explore the role of vitamin D status on QOL score in osteoporosis with high fracture risk. Methods Patients were osteoporotic women aged ≥70 years and with ≥1 risk factor for incident fracture, namely prevalent osteoporotic fracture, bone mineral density (BMD) >-3.0 SD of young adult mean, or high bone turnover marker. Health-related QOL was assessed using the Japanese Osteoporosis Quality of Life Questionnaire (JOQOL). When patients were classified into quartiles by total QOL score). Serum 25-hydroxyvitamin D (25[OH]D) level was measured by immunoassay. Results A total of 1585 osteoporotic women were included in the study (age range, 70-95 years). Age, body mass index, serum 25(OH)D status (low, normal, or high), bone mineral density, number of prevalent vertebral fractures, presence of hypertension, presence of osteoarthritis, and history of falls were significantly correlated with QOL quartile. Multivariate liner regression analysis indicated that low serum 25(OH)D level (<20 ng/mL) was an independent determinant of total QOL score quartile (P = 0.0055). The conventional determinants of QOL - age (P < 0.0001), body mass index (P = 0.0060), number of prevalent vertebral fractures (P < 0.0001), presence of osteoarthritis (P = 0.0074), and history of fall (P = 0.0098) - were also independent determinants of total QOL score. Conclusions These results strongly suggest that low serum 25(OH)D level was a significant determinant of QOL in these osteoporotic women, independently of the conventional factors that reduce QOL. Maintenance of serum 25(OH)D levels >20 ng/mL may be required to maintain patients' QOL in osteoporosis.
KW - 25(OH)D
KW - QOL
KW - fall
KW - fracture
KW - osteoporosis
UR - http://www.scopus.com/inward/record.url?scp=84894042550&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84894042550&partnerID=8YFLogxK
U2 - 10.1016/j.clinthera.2013.12.007
DO - 10.1016/j.clinthera.2013.12.007
M3 - Article
C2 - 24462224
AN - SCOPUS:84894042550
VL - 36
SP - 225
EP - 235
JO - Clinical Therapeutics
JF - Clinical Therapeutics
SN - 0149-2918
IS - 2
ER -