TY - JOUR
T1 - Serous borderline ovarian tumor with functioning stroma in a postmenopausal woman
T2 - Immunohistochemical analysis of steroidogenic pathway
AU - Yasuda, Masanori
AU - Itoh, Johbu
AU - Hirasawa, Takeshi
AU - Hirazono, Kenichi
AU - Shinozuka, Takao
AU - Sasano, Hironobu
AU - Osamura, R. Yoshiyuki
PY - 1998/1
Y1 - 1998/1
N2 - An epithelial ovarian tumor with estrogenic manifestations (vaginal bleeding, vaginal softening) was encountered in a 70-year-old woman. The preoperative serum levels of estrone, estradiol, and testosterone were elevated. A right ovarian serous papillary tumor of borderline malignancy was removed and found to have a cellular, focally luteinized stroma. Steroidogenic enzymes, including 3β-hydroxysteroid dehydrogenase and P450 cytochromes specific for cholesterol side-chain cleavage (P450scc), 17α- hydroxylation (P45017α), and aromatization (P450arom), were immunohistochemically demonstrated in the stromal cells. Immunohistochemical evaluation of these enzymes suggest significant functional differences among the enzymatically-activated stromal cells. That only rare stromal cells were immunoreactive for P450arom suggests that most of the testosterone synthesized in the tumor is extragonadally converted to estrogen, resulting in tumor-associated estrinism.
AB - An epithelial ovarian tumor with estrogenic manifestations (vaginal bleeding, vaginal softening) was encountered in a 70-year-old woman. The preoperative serum levels of estrone, estradiol, and testosterone were elevated. A right ovarian serous papillary tumor of borderline malignancy was removed and found to have a cellular, focally luteinized stroma. Steroidogenic enzymes, including 3β-hydroxysteroid dehydrogenase and P450 cytochromes specific for cholesterol side-chain cleavage (P450scc), 17α- hydroxylation (P45017α), and aromatization (P450arom), were immunohistochemically demonstrated in the stromal cells. Immunohistochemical evaluation of these enzymes suggest significant functional differences among the enzymatically-activated stromal cells. That only rare stromal cells were immunoreactive for P450arom suggests that most of the testosterone synthesized in the tumor is extragonadally converted to estrogen, resulting in tumor-associated estrinism.
KW - Functioning stroma
KW - Ovary
KW - Serous borderline tumor
KW - Steroidogenesis
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U2 - 10.1097/00004347-199801000-00013
DO - 10.1097/00004347-199801000-00013
M3 - Article
C2 - 9475196
AN - SCOPUS:0031984397
VL - 17
SP - 75
EP - 78
JO - International Journal of Gynecological Pathology
JF - International Journal of Gynecological Pathology
SN - 0277-1691
IS - 1
ER -