Serous borderline ovarian tumor with functioning stroma in a postmenopausal woman: Immunohistochemical analysis of steroidogenic pathway

Masanori Yasuda, Johbu Itoh, Takeshi Hirasawa, Kenichi Hirazono, Takao Shinozuka, Hironobu Sasano, R. Yoshiyuki Osamura

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

An epithelial ovarian tumor with estrogenic manifestations (vaginal bleeding, vaginal softening) was encountered in a 70-year-old woman. The preoperative serum levels of estrone, estradiol, and testosterone were elevated. A right ovarian serous papillary tumor of borderline malignancy was removed and found to have a cellular, focally luteinized stroma. Steroidogenic enzymes, including 3β-hydroxysteroid dehydrogenase and P450 cytochromes specific for cholesterol side-chain cleavage (P450scc), 17α- hydroxylation (P45017α), and aromatization (P450arom), were immunohistochemically demonstrated in the stromal cells. Immunohistochemical evaluation of these enzymes suggest significant functional differences among the enzymatically-activated stromal cells. That only rare stromal cells were immunoreactive for P450arom suggests that most of the testosterone synthesized in the tumor is extragonadally converted to estrogen, resulting in tumor-associated estrinism.

Original languageEnglish
Pages (from-to)75-78
Number of pages4
JournalInternational Journal of Gynecological Pathology
Volume17
Issue number1
DOIs
Publication statusPublished - 1998 Jan

Keywords

  • Functioning stroma
  • Ovary
  • Serous borderline tumor
  • Steroidogenesis

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Obstetrics and Gynaecology

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