TY - JOUR
T1 - Serotype Identification of Human Adenoviruses Associated with Influenza-Like Illnesses in the Philippines from 2006–2012 by Microneutralization and Molecular Techniques
AU - Calzado-Dacasin, Catherine
AU - Foronda, Janiza Lianne
AU - Arguelles, Vina Lea
AU - Daga, Chona Mae
AU - Quimpo, Marie Therese
AU - Lupisan, Socorro
AU - Dapat, Clyde
AU - Saito, Mariko
AU - Okamoto, Michiko
AU - Albano, Pia Marie
AU - Oshitani, Hitoshi
N1 - Funding Information:
This study was funded by the Epidemiology Bureau and the Disease Prevention and Control Bureau of the Department of Health, Philippines and by the Japan Initiative for Global Research Network for Infectious Diseases (J-GRID) under Grant Number JP19fm0108013 .
Publisher Copyright:
© 2022 The Authors
PY - 2022/4
Y1 - 2022/4
N2 - Objectives: Human adenoviruses (HAdV) are known to cause a wide range of diseases including acute respiratory infections, conjunctivitis, and acute gastroenteritis. In this study, we aimed to determine the serotypes of HAdV in patients with influenza-like illness (ILI) in the Philippines from 2006-2012 and to describe the demographic and epidemiological characteristics of patients who tested positive for HAdV. Methods: Between 2006 and 2012, the Philippine National Influenza Centre detected HAdV in 1294 samples of patients with ILI. Serotype determination was done in select samples using microneutralization, polymerase chain reaction (PCR), and sequencing methods. Results: A total of 8 serotypes were identified (HAdV 1–7 and 11), with HAdV-2 (27.8%), and HAdV-3 (27.8%) being the most prevalent. The majority of HAdV infections were found in children below 5 years of age (79.9%). Conclusions: The identification of HAdV circulating serotypes may serve as guide for designing disease intervention and control strategies and will provide important information regarding the contribution of this virus to respiratory infections, particularly in children, which remain a public health burden in the Philippines.
AB - Objectives: Human adenoviruses (HAdV) are known to cause a wide range of diseases including acute respiratory infections, conjunctivitis, and acute gastroenteritis. In this study, we aimed to determine the serotypes of HAdV in patients with influenza-like illness (ILI) in the Philippines from 2006-2012 and to describe the demographic and epidemiological characteristics of patients who tested positive for HAdV. Methods: Between 2006 and 2012, the Philippine National Influenza Centre detected HAdV in 1294 samples of patients with ILI. Serotype determination was done in select samples using microneutralization, polymerase chain reaction (PCR), and sequencing methods. Results: A total of 8 serotypes were identified (HAdV 1–7 and 11), with HAdV-2 (27.8%), and HAdV-3 (27.8%) being the most prevalent. The majority of HAdV infections were found in children below 5 years of age (79.9%). Conclusions: The identification of HAdV circulating serotypes may serve as guide for designing disease intervention and control strategies and will provide important information regarding the contribution of this virus to respiratory infections, particularly in children, which remain a public health burden in the Philippines.
KW - Human adenovirus (HAdV)
KW - PCR
KW - Philippines
KW - microneutralization
KW - sequencing
KW - serotype
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U2 - 10.1016/j.ijid.2022.02.008
DO - 10.1016/j.ijid.2022.02.008
M3 - Article
C2 - 35150916
AN - SCOPUS:85125516384
SN - 1201-9712
VL - 117
SP - 326
EP - 333
JO - International Journal of Infectious Diseases
JF - International Journal of Infectious Diseases
ER -
