Serotonin 5-HT2C receptor-independent expression of hypothalamic NOR1, a novel modulator of food intake and energy balance, in mice

Katsunori Nonogaki, Takao Kaji, Yukie Ohba, Makiko Sumii, Mamoru Wakameda, Tomohiro Tamari

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)

Abstract

NOR1, Nur77 and Nurr1 are orphan nuclear receptors and members of the NR4A subfamily. Here, we report that the expression of hypothalamic NOR1 was remarkably decreased in mildly obese β-endorphin-deficient mice and obese db/db mice with the leptin receptor mutation, compared with age-matched wild-type mice, whereas there were no genotypic differences in the expression of hypothalamic Nur77 or Nurr1 in these animals. The injection of NOR1 siRNA oligonucleotide into the third cerebral ventricle significantly suppressed food intake and body weight in mice. On the other hand, the decreases in hypothalamic NOR1 expression were not found in non-obese 5-HT2C receptor-deficient mice. Moreover, systemic administration of m-chlorophenylpiperazine (mCPP), a 5-HT2C/1B receptor agonist, had no effect on hypothalamic NOR1 expression, while suppressing food intake in β-endorphin-deficient mice. These findings suggest that 5-HT2C receptor-independent proopiomelanocortin-derived peptides regulate the expression of hypothalamic NOR1, which is a novel modulator of feeding behavior and energy balance.

Original languageEnglish
Pages (from-to)311-315
Number of pages5
JournalBiochemical and biophysical research communications
Volume386
Issue number2
DOIs
Publication statusPublished - 2009 Aug 21

Keywords

  • 5-HT
  • 5-HT2C receptor
  • Food intake
  • Hypothalamus
  • Leptin receptor
  • NOR1
  • NR4A
  • Obesity
  • Proopiomelanocortin-derived peptides
  • β-Endorphin

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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