Serotonergic neuronal death and concomitant serotonin deficiency curb copulation ability of Drosophila platonic mutants

Yasemin B. Yilmazer, Masayuki Koganezawa, Kosei Sato, Jinhua Xu, Daisuke Yamamoto

    Research output: Contribution to journalArticlepeer-review

    4 Citations (Scopus)

    Abstract

    Drosophila platonic (plt) males court females, but fail to copulate. Here we show that plt is an allele of scribbler (sbb), a BMP signalling component. sbb knockdown in larvae leads to the loss of approximately eight serotonergic neurons, which express the sex-determinant protein Doublesex (Dsx). Genetic deprivation of serotonin (5-HT) from dsx-expressing neurons results in copulation defects. Thus, sbb+ is developmentally required for the survival of a specific subset of dsx-expressing neurons, which support the normal execution of copulation in adults by providing 5-HT. Our study highlights the conserved involvement of serotonergic neurons in the control of copulatory mechanisms and the key role of BMP signalling in the formation of a sex-specific circuitry.

    Original languageEnglish
    Article number13792
    JournalNature communications
    Volume7
    DOIs
    Publication statusPublished - 2016 Dec 13

    ASJC Scopus subject areas

    • Chemistry(all)
    • Biochemistry, Genetics and Molecular Biology(all)
    • Physics and Astronomy(all)

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