O espectro da neuromielite optica seronegativa - Os desafios na definição da doença e sua patogênese

Douglas Kazutoshi Sato; Dagoberto Callegaro; Marco Aurélio Lana-Peixoto; Ichiro Nakashima; Kazuo Fujihara

doi:10.1590/0004-282X20140032

O espectro da neuromielite optica seronegativa - Os desafios na definição da doença e sua patogênese

Translated title of the contribution: Seronegative neuromyelitis optica spectrum - The challenges on disease definition and pathogenesis

Douglas Kazutoshi Sato, Dagoberto Callegaro, Marco Aurélio Lana-Peixoto, Ichiro Nakashima, Kazuo Fujihara

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

Abstract

Neuromyelitis optica spectrum disorders (NMOSD) are characterized by severe optic neuritis and/or longitudinally extensive transverse myelitis, and some brain lesions are also unique to NMOSD. Serum autoantibodies against aquaporin-4 (AQP4) are detected in most cases of NMOSD. However, some patients with NMOSD remain seronegative despite repetitive testing during attacks with highly sensitive cellbased assays. The differential diagnosis of NMOSD is not restricted to multiple sclerosis and it includes many diseases that can produce longitudinally extensive myelitis and/or optic neuritis. We review the clinical features, imaging, and laboratory findings that can be helpful on the diagnostic work-up, discuss the differences between AQP4 antibody positive and negative patients with NMOSD, including features of NMOSD with antibodies against myelin oligodendrocyte glycoprotein.

Translated title of the contribution	Seronegative neuromyelitis optica spectrum - The challenges on disease definition and pathogenesis
Original language	Portuguese
Pages (from-to)	445-450
Number of pages	6
Journal	Arquivos de Neuro-Psiquiatria
Volume	72
Issue number	6
DOIs	https://doi.org/10.1590/0004-282X20140032
Publication status	Published - 2014 Jun

Keywords

Antibody
Aquaporin-4
Differential diagnosis
Myelin oligodendrocyte glycoprotein
Myelitis
Neuromyelitis optica
Optic neuritis

ASJC Scopus subject areas

Clinical Neurology
Biological Psychiatry

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10.1590/0004-282X20140032

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title = "O espectro da neuromielite optica seronegativa - Os desafios na defini{\c c}{\~a}o da doen{\c c}a e sua patog{\^e}nese",

abstract = "Neuromyelitis optica spectrum disorders (NMOSD) are characterized by severe optic neuritis and/or longitudinally extensive transverse myelitis, and some brain lesions are also unique to NMOSD. Serum autoantibodies against aquaporin-4 (AQP4) are detected in most cases of NMOSD. However, some patients with NMOSD remain seronegative despite repetitive testing during attacks with highly sensitive cellbased assays. The differential diagnosis of NMOSD is not restricted to multiple sclerosis and it includes many diseases that can produce longitudinally extensive myelitis and/or optic neuritis. We review the clinical features, imaging, and laboratory findings that can be helpful on the diagnostic work-up, discuss the differences between AQP4 antibody positive and negative patients with NMOSD, including features of NMOSD with antibodies against myelin oligodendrocyte glycoprotein.",

keywords = "Antibody, Aquaporin-4, Differential diagnosis, Myelin oligodendrocyte glycoprotein, Myelitis, Neuromyelitis optica, Optic neuritis",

author = "Sato, {Douglas Kazutoshi} and Dagoberto Callegaro and Lana-Peixoto, {Marco Aur{\'e}lio} and Ichiro Nakashima and Kazuo Fujihara",

year = "2014",

month = jun,

doi = "10.1590/0004-282X20140032",

language = "Portuguese",

volume = "72",

pages = "445--450",

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T1 - O espectro da neuromielite optica seronegativa - Os desafios na definição da doença e sua patogênese

AU - Sato, Douglas Kazutoshi

AU - Callegaro, Dagoberto

AU - Lana-Peixoto, Marco Aurélio

AU - Nakashima, Ichiro

AU - Fujihara, Kazuo

PY - 2014/6

Y1 - 2014/6

N2 - Neuromyelitis optica spectrum disorders (NMOSD) are characterized by severe optic neuritis and/or longitudinally extensive transverse myelitis, and some brain lesions are also unique to NMOSD. Serum autoantibodies against aquaporin-4 (AQP4) are detected in most cases of NMOSD. However, some patients with NMOSD remain seronegative despite repetitive testing during attacks with highly sensitive cellbased assays. The differential diagnosis of NMOSD is not restricted to multiple sclerosis and it includes many diseases that can produce longitudinally extensive myelitis and/or optic neuritis. We review the clinical features, imaging, and laboratory findings that can be helpful on the diagnostic work-up, discuss the differences between AQP4 antibody positive and negative patients with NMOSD, including features of NMOSD with antibodies against myelin oligodendrocyte glycoprotein.

AB - Neuromyelitis optica spectrum disorders (NMOSD) are characterized by severe optic neuritis and/or longitudinally extensive transverse myelitis, and some brain lesions are also unique to NMOSD. Serum autoantibodies against aquaporin-4 (AQP4) are detected in most cases of NMOSD. However, some patients with NMOSD remain seronegative despite repetitive testing during attacks with highly sensitive cellbased assays. The differential diagnosis of NMOSD is not restricted to multiple sclerosis and it includes many diseases that can produce longitudinally extensive myelitis and/or optic neuritis. We review the clinical features, imaging, and laboratory findings that can be helpful on the diagnostic work-up, discuss the differences between AQP4 antibody positive and negative patients with NMOSD, including features of NMOSD with antibodies against myelin oligodendrocyte glycoprotein.

KW - Antibody

KW - Aquaporin-4

KW - Differential diagnosis

KW - Myelin oligodendrocyte glycoprotein

KW - Myelitis

KW - Neuromyelitis optica

KW - Optic neuritis

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O espectro da neuromielite optica seronegativa - Os desafios na definição da doença e sua patogênese

Abstract

Keywords

ASJC Scopus subject areas

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