O espectro da neuromielite optica seronegativa - Os desafios na definição da doença e sua patogênese

Translated title of the contribution: Seronegative neuromyelitis optica spectrum - The challenges on disease definition and pathogenesis

Douglas Kazutoshi Sato, Dagoberto Callegaro, Marco Aurélio Lana-Peixoto, Ichiro Nakashima, Kazuo Fujihara

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)

Abstract

Neuromyelitis optica spectrum disorders (NMOSD) are characterized by severe optic neuritis and/or longitudinally extensive transverse myelitis, and some brain lesions are also unique to NMOSD. Serum autoantibodies against aquaporin-4 (AQP4) are detected in most cases of NMOSD. However, some patients with NMOSD remain seronegative despite repetitive testing during attacks with highly sensitive cellbased assays. The differential diagnosis of NMOSD is not restricted to multiple sclerosis and it includes many diseases that can produce longitudinally extensive myelitis and/or optic neuritis. We review the clinical features, imaging, and laboratory findings that can be helpful on the diagnostic work-up, discuss the differences between AQP4 antibody positive and negative patients with NMOSD, including features of NMOSD with antibodies against myelin oligodendrocyte glycoprotein.

Translated title of the contributionSeronegative neuromyelitis optica spectrum - The challenges on disease definition and pathogenesis
Original languagePortuguese
Pages (from-to)445-450
Number of pages6
JournalArquivos de Neuro-Psiquiatria
Volume72
Issue number6
DOIs
Publication statusPublished - 2014 Jun

Keywords

  • Antibody
  • Aquaporin-4
  • Differential diagnosis
  • Myelin oligodendrocyte glycoprotein
  • Myelitis
  • Neuromyelitis optica
  • Optic neuritis

ASJC Scopus subject areas

  • Clinical Neurology
  • Biological Psychiatry

Fingerprint Dive into the research topics of 'Seronegative neuromyelitis optica spectrum - The challenges on disease definition and pathogenesis'. Together they form a unique fingerprint.

Cite this