Serine palmitoyltransferase, the first step enzyme in sphingolipid biosynthesis, is involved in nonhost resistance

Yoshihiro Takahashi, Thomas Berberich, Hiroyuki Kanzaki, Hideo Matsumura, Hiromasa Saitoh, Tomonobu Kusano, Ryohei Terauchi

    Research output: Contribution to journalArticlepeer-review

    29 Citations (Scopus)

    Abstract

    An overexpression screen of Nicotiana benthamiana cDNAs identified a gene for the LCB2 subunit of serine palmitoyltransferase (SPT) as a potent inducer of hypersensitive response-like cell death. The pyridoxal 5′-phosphate binding site of NbLCB2 is required for its function as a cell death inducer. NbLCB2 mRNA is accumulated after infection by nonhost pathogen Pseudomonas cichorii. Resistance of N. benthamiana against P. cichorii was compromised by treatment with an SPT inhibitor and in NbLCB2- and NbLCB1-silenced plants. These results suggest that biosynthesis of sphingolipids is necessary for the nonhost resistance of N. benthamiana against P. cichorii.

    Original languageEnglish
    Pages (from-to)31-38
    Number of pages8
    JournalMolecular Plant-Microbe Interactions
    Volume22
    Issue number1
    DOIs
    Publication statusPublished - 2009 Jan

    ASJC Scopus subject areas

    • Physiology
    • Agronomy and Crop Science

    Fingerprint Dive into the research topics of 'Serine palmitoyltransferase, the first step enzyme in sphingolipid biosynthesis, is involved in nonhost resistance'. Together they form a unique fingerprint.

    Cite this