Serine palmitoyltransferase, the first step enzyme in sphingolipid biosynthesis, is involved in nonhost resistance

Yoshihiro Takahashi, Thomas Berberich, Hiroyuki Kanzaki, Hideo Matsumura, Hiromasa Saitoh, Tomonobu Kusano, Ryohei Terauchi

Research output: Contribution to journalArticlepeer-review

32 Citations (Scopus)

Abstract

An overexpression screen of Nicotiana benthamiana cDNAs identified a gene for the LCB2 subunit of serine palmitoyltransferase (SPT) as a potent inducer of hypersensitive response-like cell death. The pyridoxal 5′-phosphate binding site of NbLCB2 is required for its function as a cell death inducer. NbLCB2 mRNA is accumulated after infection by nonhost pathogen Pseudomonas cichorii. Resistance of N. benthamiana against P. cichorii was compromised by treatment with an SPT inhibitor and in NbLCB2- and NbLCB1-silenced plants. These results suggest that biosynthesis of sphingolipids is necessary for the nonhost resistance of N. benthamiana against P. cichorii.

Original languageEnglish
Pages (from-to)31-38
Number of pages8
JournalMolecular Plant-Microbe Interactions
Volume22
Issue number1
DOIs
Publication statusPublished - 2009 Jan
Externally publishedYes

ASJC Scopus subject areas

  • Physiology
  • Agronomy and Crop Science

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